Difference between revisions of "YJL092W"
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003628 YJL092W] | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003628 YJL092W] | ||
|- | |- | ||
| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||'' | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SRS2 '' |
|- | |- | ||
| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||''RADH, RADH1 | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases''' ||''HPR5, RADH, RADH1'' |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]] | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type''' || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]] | ||
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr X: | + | |nowrap| Chr X:257417..260941 |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003628 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003628 | ||
|} | |} | ||
<br> | <br> | ||
| − | '''Description of YJL092W:''' DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; affects genome stability by | + | '''Description of YJL092W:''' DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability<ref name='S000126247'>Dhar A and Lahue RS (2008) Rapid unwinding of triplet repeat hairpins by Srs2 helicase of Saccharomyces cerevisiae. Nucleic Acids Res 36(10):3366-73 {{SGDpaper|S000126247}} PMID 18440969</ref><ref name='S000086095'>Papouli E, et al. (2005) Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p. Mol Cell 19(1):123-33 {{SGDpaper|S000086095}} PMID 15989970</ref><ref name='S000081912'>Pfander B, et al. (2005) SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase. Nature 436(7049):428-33 {{SGDpaper|S000081912}} PMID 15931174</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref><ref name='S000051638'>Rong L and Klein HL (1993) Purification and characterization of the SRS2 DNA helicase of the yeast Saccharomyces cerevisiae. J Biol Chem 268(2):1252-9 {{SGDpaper|S000051638}} PMID 8419328</ref><ref name='S000044473'>Aboussekhra A, et al. (1989) RADH, a gene of Saccharomyces cerevisiae encoding a putative DNA helicase involved in DNA repair. Characteristics of radH mutants and sequence of the gene. Nucleic Acids Res 17(18):7211-9 {{SGDpaper|S000044473}} PMID 2552405</ref><ref name='S000044035'>Palladino F and Klein HL (1992) Analysis of mitotic and meiotic defects in Saccharomyces cerevisiae SRS2 DNA helicase mutants. Genetics 132(1):23-37 |
{{SGDpaper|S000044035}} PMID 1327956</ref> | {{SGDpaper|S000044035}} PMID 1327956</ref> | ||
<br> | <br> | ||
Revision as of 07:21, 26 February 2009
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| Systematic name | YJL092W |
| Gene name | SRS2 |
| Aliases | HPR5, RADH, RADH1 |
| Feature type | ORF, Verified |
| Coordinates | Chr X:257417..260941 |
| Primary SGDID | S000003628 |
Description of YJL092W: DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability[1][2][3][4][5][6][7]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [4] [8]
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References
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- ↑ Dhar A and Lahue RS (2008) Rapid unwinding of triplet repeat hairpins by Srs2 helicase of Saccharomyces cerevisiae. Nucleic Acids Res 36(10):3366-73 SGD PMID 18440969
- ↑ Papouli E, et al. (2005) Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p. Mol Cell 19(1):123-33 SGD PMID 15989970
- ↑ Pfander B, et al. (2005) SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase. Nature 436(7049):428-33 SGD PMID 15931174
- ↑ 4.0 4.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ Rong L and Klein HL (1993) Purification and characterization of the SRS2 DNA helicase of the yeast Saccharomyces cerevisiae. J Biol Chem 268(2):1252-9 SGD PMID 8419328
- ↑ Aboussekhra A, et al. (1989) RADH, a gene of Saccharomyces cerevisiae encoding a putative DNA helicase involved in DNA repair. Characteristics of radH mutants and sequence of the gene. Nucleic Acids Res 17(18):7211-9 SGD PMID 2552405
- ↑ Palladino F and Klein HL (1992) Analysis of mitotic and meiotic defects in Saccharomyces cerevisiae SRS2 DNA helicase mutants. Genetics 132(1):23-37 SGD PMID 1327956
- ↑ submitted by Jeff Ubersax on 2004-01-27
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