Difference between revisions of "YJL012C"

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'''Description of YJL012C:''' Vacuolar membrane polyphosphate polymerase; subunit of the vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to the vacuole; regulates membrane trafficking; role in non-autophagic vacuolar fusion<ref name='S000040168'>Cohen A, et al. (1999) A novel family of yeast chaperons involved in the distribution of V-ATPase and other membrane proteins. J Biol Chem 274(38):26885-93 {{SGDpaper|S000040168}} PMID 10480897</ref><ref name='S000059109'>Ogawa N, et al. (2000) New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysis. Mol Biol Cell 11(12):4309-21 {{SGDpaper|S000059109}} PMID 11102525</ref><ref name='S000069426'>Muller O, et al. (2002) The Vtc proteins in vacuole fusion: coupling NSF activity to V(0) trans-complex formation. EMBO J 21(3):259-69 {{SGDpaper|S000069426}} PMID 11823419</ref><ref name='S000074092'>Muller O, et al. (2003) Role of the Vtc proteins in V-ATPase stability and membrane trafficking. J Cell Sci 116(Pt 6):1107-15 {{SGDpaper|S000074092}} PMID 12584253</ref><ref name='S000131552'>Hothorn M, et al. (2009) Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase. Science 324(5926):513-6 {{SGDpaper|S000131552}} PMID 19390046</ref><ref name='S000123834'>Uttenweiler A, et al. (2007) The vacuolar transporter chaperone (VTC) complex is required for microautophagy. Mol Biol Cell 18(1):166-75
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'''Description of YJL012C:''' Vacuolar membrane polyphosphate polymerase; subunit of the vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to the vacuole; regulates membrane trafficking; role in non-autophagic vacuolar fusion<ref name='S000040168'>Cohen A, et al. (1999) A novel family of yeast chaperons involved in the distribution of V-ATPase and other membrane proteins. J Biol Chem 274(38):26885-93 {{SGDpaper|S000040168}} PMID 10480897</ref><ref name='S000131552'>Hothorn M, et al. (2009) Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase. Science 324(5926):513-6 {{SGDpaper|S000131552}} PMID 19390046</ref><ref name='S000069426'>Muller O, et al. (2002) The Vtc proteins in vacuole fusion: coupling NSF activity to V(0) trans-complex formation. EMBO J 21(3):259-69 {{SGDpaper|S000069426}} PMID 11823419</ref><ref name='S000074092'>Muller O, et al. (2003) Role of the Vtc proteins in V-ATPase stability and membrane trafficking. J Cell Sci 116(Pt 6):1107-15 {{SGDpaper|S000074092}} PMID 12584253</ref><ref name='S000059109'>Ogawa N, et al. (2000) New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysis. Mol Biol Cell 11(12):4309-21 {{SGDpaper|S000059109}} PMID 11102525</ref><ref name='S000123834'>Uttenweiler A, et al. (2007) The vacuolar transporter chaperone (VTC) complex is required for microautophagy. Mol Biol Cell 18(1):166-75
 
  {{SGDpaper|S000123834}} PMID 17079729</ref>
 
  {{SGDpaper|S000123834}} PMID 17079729</ref>
 
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Revision as of 14:05, 25 February 2010

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Systematic name YJL012C
Gene name VTC4
Aliases PHM3, YJL012C-A
Feature type ORF, Verified
Coordinates Chr X:413392..411227
Primary SGDID S000003549


Description of YJL012C: Vacuolar membrane polyphosphate polymerase; subunit of the vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to the vacuole; regulates membrane trafficking; role in non-autophagic vacuolar fusion[1][2][3][4][5][6]




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DNA and RNA Details

Other DNA and RNA Details

Other Topic: expression

Specifically higher expression in phosphorus limited chemostat cultures versus phosphorus excess. [7] [8]





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References

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  1. Cohen A, et al. (1999) A novel family of yeast chaperons involved in the distribution of V-ATPase and other membrane proteins. J Biol Chem 274(38):26885-93 SGD PMID 10480897
  2. Hothorn M, et al. (2009) Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase. Science 324(5926):513-6 SGD PMID 19390046
  3. Muller O, et al. (2002) The Vtc proteins in vacuole fusion: coupling NSF activity to V(0) trans-complex formation. EMBO J 21(3):259-69 SGD PMID 11823419
  4. Muller O, et al. (2003) Role of the Vtc proteins in V-ATPase stability and membrane trafficking. J Cell Sci 116(Pt 6):1107-15 SGD PMID 12584253
  5. Ogawa N, et al. (2000) New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysis. Mol Biol Cell 11(12):4309-21 SGD PMID 11102525
  6. Uttenweiler A, et al. (2007) The vacuolar transporter chaperone (VTC) complex is required for microautophagy. Mol Biol Cell 18(1):166-75 SGD PMID 17079729
  7. Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
  8. submitted by Viktor Boer on 2003-07-25

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