Difference between revisions of "YIR019C"
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| − | '''Description of YIR019C:''' GPI-anchored cell surface glycoprotein (flocculin) required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p)<ref name=' | + | '''Description of YIR019C:''' GPI-anchored cell surface glycoprotein (flocculin) required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p)<ref name='S000051172'>Rupp S, et al. (1999) MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene. EMBO J 18(5):1257-69 {{SGDpaper|S000051172}} PMID 10064592</ref><ref name='S000055959'>Lambrechts MG, et al. (1996) Muc1, a mucin-like protein that is regulated by Mss10, is critical for pseudohyphal differentiation in yeast. Proc Natl Acad Sci U S A 93(16):8419-24 {{SGDpaper|S000055959}} PMID 8710886</ref><ref name='S000061547'>Guo B, et al. (2000) A Saccharomyces gene family involved in invasive growth, cell-cell adhesion, and mating. Proc Natl Acad Sci U S A 97(22):12158-63 {{SGDpaper|S000061547}} PMID 11027318</ref><ref name='S000124375'>Douglas LM, et al. (2007) Expression and Characterization of the Flocculin Flo11/Muc1, a Saccharomyces cerevisiae Mannoprotein with Homotypic Properties of Adhesion. Eukaryot Cell 6(12):2214-21 |
| − | {{SGDpaper| | + | {{SGDpaper|S000124375}} PMID 17921350</ref> |
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Revision as of 04:40, 18 December 2008
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| Systematic name | YIR019C |
| Gene name | MUC1 |
| Aliases | FLO11, STA4 |
| Feature type | ORF, Verified |
| Coordinates | Chr IX:393672..389569 |
| Primary SGDID | S000001458 |
Description of YIR019C: GPI-anchored cell surface glycoprotein (flocculin) required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p)[1][2][3][4]
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Contents
Community Commentary
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Alleles, Strains, and Phenotypes
Multiple Knockout Strains
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4618
Together with: REG1, SIP1, GAL83, SIP2
Phenotype(s): Loss of function (Null), FLO11/MUC1 promoter substituted with S.p.Adh+ promoter
Deletion of REG1 in cells where FLO11/MUC1 expression is clamped (by substitution of the FLO11 promoter with the S.pombe Adh+promoter) causes an increase in invasion. [5] [6]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4469
Together with: REG1, SIP1, GAL83, SIP2
Phenotype(s): Loss of function (Null)
Deletion of FLO11/MUC1 suppresses reg1's constitutive invasion phenotype, but not its constitutive filamentous phenotype. [5] [6]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4618
Together with: REG1, SIP1, GAL83, SIP2
Phenotype(s): Loss of function (Null), FLO11/MUC1 promoter substituted with S.p.Adh+ promoter
Deletion of REG1 in cells where FLO11/MUC1 expression is clamped (by substitution of the FLO11 promoter with the S.pombe Adh+promoter) causes an increase in invasion. [5] [6]
Strain Background: Sigma1278b (Sigma2000 series)
Genotype: MCY4469
Together with: REG1, SIP1, GAL83, SIP2
Phenotype(s): Loss of function (Null)
Deletion of FLO11/MUC1 suppresses reg1's constitutive invasion phenotype, but not its constitutive filamentous phenotype. [5] [6]
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References
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- ↑ Rupp S, et al. (1999) MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene. EMBO J 18(5):1257-69 SGD PMID 10064592
- ↑ Lambrechts MG, et al. (1996) Muc1, a mucin-like protein that is regulated by Mss10, is critical for pseudohyphal differentiation in yeast. Proc Natl Acad Sci U S A 93(16):8419-24 SGD PMID 8710886
- ↑ Guo B, et al. (2000) A Saccharomyces gene family involved in invasive growth, cell-cell adhesion, and mating. Proc Natl Acad Sci U S A 97(22):12158-63 SGD PMID 11027318
- ↑ Douglas LM, et al. (2007) Expression and Characterization of the Flocculin Flo11/Muc1, a Saccharomyces cerevisiae Mannoprotein with Homotypic Properties of Adhesion. Eukaryot Cell 6(12):2214-21 SGD PMID 17921350
- ↑ 5.0 5.1 5.2 5.3 Vyas VK, et al. (2003) Snf1 kinases with different beta-subunit isoforms play distinct roles in regulating haploid invasive growth. Mol Cell Biol 23(4):1341-8 SGD PMID 12556493
- ↑ 6.0 6.1 6.2 6.3 submitted by Valmik K. Vyas on 2003-03-27
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