Difference between revisions of "YIL106W"
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| − | '''Description of YIL106W:''' Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex<ref name=' | + | '''Description of YIL106W:''' Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex<ref name='S000047704'>Luca FC and Winey M (1998) MOB1, an essential yeast gene required for completion of mitosis and maintenance of ploidy. Mol Biol Cell 9(1):29-46 {{SGDpaper|S000047704}} PMID 9436989</ref><ref name='S000052118'>Komarnitsky SI, et al. (1998) DBF2 protein kinase binds to and acts through the cell cycle-regulated MOB1 protein. Mol Cell Biol 18(4):2100-7 {{SGDpaper|S000052118}} PMID 9528782</ref><ref name='S000060813'>Yoshida S and Toh-e A (2001) Regulation of the localization of Dbf2 and mob1 during cell division of saccharomyces cerevisiae. Genes Genet Syst 76(2):141-7 {{SGDpaper|S000060813}} PMID 11434459</ref><ref name='S000061406'>Mah AS, et al. (2001) Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex. Proc Natl Acad Sci U S A 98(13):7325-30 {{SGDpaper|S000061406}} PMID 11404483</ref><ref name='S000066135'>Luca FC, et al. (2001) Saccharomyces cerevisiae Mob1p is required for cytokinesis and mitotic exit. Mol Cell Biol 21(20):6972-83 |
| − | {{SGDpaper| | + | {{SGDpaper|S000066135}} PMID 11564880</ref> |
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Revision as of 04:40, 18 December 2008
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| Systematic name | YIL106W |
| Gene name | MOB1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IX:166412..167441 |
| Primary SGDID | S000001368 |
Description of YIL106W: Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex[1][2][3][4][5]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [6] [7]
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References
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- ↑ Luca FC and Winey M (1998) MOB1, an essential yeast gene required for completion of mitosis and maintenance of ploidy. Mol Biol Cell 9(1):29-46 SGD PMID 9436989
- ↑ Komarnitsky SI, et al. (1998) DBF2 protein kinase binds to and acts through the cell cycle-regulated MOB1 protein. Mol Cell Biol 18(4):2100-7 SGD PMID 9528782
- ↑ Yoshida S and Toh-e A (2001) Regulation of the localization of Dbf2 and mob1 during cell division of saccharomyces cerevisiae. Genes Genet Syst 76(2):141-7 SGD PMID 11434459
- ↑ Mah AS, et al. (2001) Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex. Proc Natl Acad Sci U S A 98(13):7325-30 SGD PMID 11404483
- ↑ Luca FC, et al. (2001) Saccharomyces cerevisiae Mob1p is required for cytokinesis and mitotic exit. Mol Cell Biol 21(20):6972-83 SGD PMID 11564880
- ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ submitted by Jeff Ubersax on 2004-01-27
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