YIL065C

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Systematic name YIL065C
Gene name FIS1
Aliases MDV2
Feature type ORF, Verified
Coordinates Chr IX:241772..241305
Primary SGDID S000001327


Description of YIL065C: Mitochondrial outer membrane protein involved in membrane fission, required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation[1][2]




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References

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  1. Mozdy AD, et al. (2000) Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p. J Cell Biol 151(2):367-80 SGD PMID 11038183
  2. Kitagaki H, et al. (2007) Ethanol-induced death in yeast exhibits features of apoptosis mediated by mitochondrial fission pathway. FEBS Lett 581(16):2935-42 SGD PMID 17544409

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