Difference between revisions of "YIL061C"

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'''Description of YIL061C:''' Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein<ref name='S000136265'>Chen YC, et al. (2010) Protein Arginine Methylation Facilitates Co-transcriptional Recruitment of pre-mRNA Splicing Factors. Mol Cell Biol () {{SGDpaper|S000136265}} PMID 20823272</ref><ref name='S000076887'>Gunderson SI, et al. (1998) U1 snRNP inhibits pre-mRNA polyadenylation through a direct interaction between U1 70K and poly(A) polymerase. Mol Cell 1(2):255-64 {{SGDpaper|S000076887}} PMID 9659922</ref><ref name='S000043875'>Hilleren PJ, et al. (1995) The amino-terminal domain of yeast U1-70K is necessary and sufficient for function. Mol Cell Biol 15(11):6341-50 {{SGDpaper|S000043875}} PMID 7565787</ref><ref name='S000056496'>Kao HY and Siliciano PG (1992) The yeast homolog of the U1 snRNP protein 70K is encoded by the SNP1 gene. Nucleic Acids Res 20(15):4009-13 {{SGDpaper|S000056496}} PMID 1387202</ref><ref name='S000045702'>Neubauer G, et al. (1997) Identification of the proteins of the yeast U1 small nuclear ribonucleoprotein complex by mass spectrometry. Proc Natl Acad Sci U S A 94(2):385-90 {{SGDpaper|S000045702}} PMID 9012791</ref><ref name='S000054305'>Smith V and Barrell BG (1991) Cloning of a yeast U1 snRNP 70K protein homologue: functional conservation of an RNA-binding domain between humans and yeast. EMBO J 10(9):2627-34
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'''Description of YIL061C:''' Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein<ref name='S000136265'>Chen YC, et al. (2010) Protein Arginine Methylation Facilitates Cotranscriptional Recruitment of Pre-mRNA Splicing Factors. Mol Cell Biol 30(21):5245-56 {{SGDpaper|S000136265}} PMID 20823272</ref><ref name='S000076887'>Gunderson SI, et al. (1998) U1 snRNP inhibits pre-mRNA polyadenylation through a direct interaction between U1 70K and poly(A) polymerase. Mol Cell 1(2):255-64 {{SGDpaper|S000076887}} PMID 9659922</ref><ref name='S000043875'>Hilleren PJ, et al. (1995) The amino-terminal domain of yeast U1-70K is necessary and sufficient for function. Mol Cell Biol 15(11):6341-50 {{SGDpaper|S000043875}} PMID 7565787</ref><ref name='S000056496'>Kao HY and Siliciano PG (1992) The yeast homolog of the U1 snRNP protein 70K is encoded by the SNP1 gene. Nucleic Acids Res 20(15):4009-13 {{SGDpaper|S000056496}} PMID 1387202</ref><ref name='S000045702'>Neubauer G, et al. (1997) Identification of the proteins of the yeast U1 small nuclear ribonucleoprotein complex by mass spectrometry. Proc Natl Acad Sci U S A 94(2):385-90 {{SGDpaper|S000045702}} PMID 9012791</ref><ref name='S000054305'>Smith V and Barrell BG (1991) Cloning of a yeast U1 snRNP 70K protein homologue: functional conservation of an RNA-binding domain between humans and yeast. EMBO J 10(9):2627-34
 
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  {{SGDpaper|S000054305}} PMID 1714384</ref>
 
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Revision as of 14:05, 16 October 2010

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Systematic name YIL061C
Gene name SNP1
Aliases
Feature type ORF, Verified
Coordinates Chr IX:245556..244654
Primary SGDID S000001323


Description of YIL061C: Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein[1][2][3][4][5][6]




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Interactions

Two Hybrid

Two Hybrid interaction with NAM7
Yeast Two-Hybrid screen with Upf1p as bait identified several interacting proteins [7] [8]


Two Hybrid interaction with Prp8
Prp8 interacts with the U1snRNP protein Snp1 [9] [10]





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References

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  1. Chen YC, et al. (2010) Protein Arginine Methylation Facilitates Cotranscriptional Recruitment of Pre-mRNA Splicing Factors. Mol Cell Biol 30(21):5245-56 SGD PMID 20823272
  2. Gunderson SI, et al. (1998) U1 snRNP inhibits pre-mRNA polyadenylation through a direct interaction between U1 70K and poly(A) polymerase. Mol Cell 1(2):255-64 SGD PMID 9659922
  3. Hilleren PJ, et al. (1995) The amino-terminal domain of yeast U1-70K is necessary and sufficient for function. Mol Cell Biol 15(11):6341-50 SGD PMID 7565787
  4. Kao HY and Siliciano PG (1992) The yeast homolog of the U1 snRNP protein 70K is encoded by the SNP1 gene. Nucleic Acids Res 20(15):4009-13 SGD PMID 1387202
  5. Neubauer G, et al. (1997) Identification of the proteins of the yeast U1 small nuclear ribonucleoprotein complex by mass spectrometry. Proc Natl Acad Sci U S A 94(2):385-90 SGD PMID 9012791
  6. Smith V and Barrell BG (1991) Cloning of a yeast U1 snRNP 70K protein homologue: functional conservation of an RNA-binding domain between humans and yeast. EMBO J 10(9):2627-34 SGD PMID 1714384
  7. He F and Jacobson A (1995) Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. Genes Dev 9(4):437-54 SGD PMID 7883168
  8. submitted by Jurgen Wittmann on 2003-04-30
  9. Awasthi S, et al. (2001) New roles for the Snp1 and Exo84 proteins in yeast pre-mRNA splicing. J Biol Chem 276(33):31004-15 SGD PMID 11425851
  10. submitted by Richard Grainger on 2003-04-11

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