YHR176W

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Systematic name YHR176W
Gene name FMO1
Aliases
Feature type ORF, Verified
Coordinates Chr VIII:454229..455527
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Description of YHR176W: Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins[1][2]



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References

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  1. Zhang M and Robertus JD (2002) Molecular cloning and characterization of a full-length flavin-dependent monooxygenase from yeast. Arch Biochem Biophys 403(2):277-83 SGD PMID 12139977
  2. Suh JK, et al. (1999) Yeast flavin-containing monooxygenase generates oxidizing equivalents that control protein folding in the endoplasmic reticulum. Proc Natl Acad Sci U S A 96(6):2687-91 SGD PMID 10077572

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