Difference between revisions of "YHR164C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YHR164C YHR164C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001207 YHR164C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''DNA2 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''DNA2 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
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|nowrap| Chr VIII:429180..424612
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|nowrap| Chr VIII:429178..424610
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000001207
 
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'''Description of {{PAGENAME}}:''' Essential tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair pathways; potential Cdc28p substrate<ref name='S000059423'>Bae SH and Seo YS (2000) Characterization of the enzymatic properties of the yeast dna2 Helicase/endonuclease suggests a new model for Okazaki fragment processing. J Biol Chem 275(48):38022-31 {{SGDpaper|S000059423}} PMID 10984490</ref><ref name='S000053505'>Bae SH, et al. (1998) Dna2 of Saccharomyces cerevisiae possesses a single-stranded DNA-specific endonuclease activity that is able to act on double-stranded DNA in the presence of ATP. J Biol Chem 273(41):26880-90 {{SGDpaper|S000053505}} PMID 9756935</ref><ref name='S000052151'>Schlesinger MB and Formosa T (2000) POB3 is required for both transcription and replication in the yeast Saccharomyces cerevisiae. Genetics 155(4):1593-606 {{SGDpaper|S000052151}} PMID 10924459</ref><ref name='S000051251'>Budd ME and Campbell JL (1997) A yeast replicative helicase, Dna2 helicase, interacts with yeast FEN-1 nuclease in carrying out its essential function. Mol Cell Biol 17(4):2136-42 {{SGDpaper|S000051251}} PMID 9121462</ref><ref name='S000039702'>Budd ME and Campbell JL (2000) The pattern of sensitivity of yeast dna2 mutants to DNA damaging agents suggests a role in DSB and postreplication repair pathways. Mutat Res 459(3):173-86
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'''Description of YHR164C:''' Tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization<ref name='S000059423'>Bae SH and Seo YS (2000) Characterization of the enzymatic properties of the yeast dna2 Helicase/endonuclease suggests a new model for Okazaki fragment processing. J Biol Chem 275(48):38022-31 {{SGDpaper|S000059423}} PMID 10984490</ref><ref name='S000053505'>Bae SH, et al. (1998) Dna2 of Saccharomyces cerevisiae possesses a single-stranded DNA-specific endonuclease activity that is able to act on double-stranded DNA in the presence of ATP. J Biol Chem 273(41):26880-90 {{SGDpaper|S000053505}} PMID 9756935</ref><ref name='S000143285'>Balakrishnan L, et al. (2010) Dna2 exhibits a unique strand end-dependent helicase function. J Biol Chem 285(50):38861-8 {{SGDpaper|S000143285}} PMID 20929864</ref><ref name='S000051251'>Budd ME and Campbell JL (1997) A yeast replicative helicase, Dna2 helicase, interacts with yeast FEN-1 nuclease in carrying out its essential function. Mol Cell Biol 17(4):2136-42 {{SGDpaper|S000051251}} PMID 9121462</ref><ref name='S000039702'>Budd ME and Campbell JL (2000) The pattern of sensitivity of yeast dna2 mutants to DNA damaging agents suggests a role in DSB and postreplication repair pathways. Mutat Res 459(3):173-86 {{SGDpaper|S000039702}} PMID 10812329</ref><ref name='S000130607'>Kosugi S, et al. (2009) Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs. Proc Natl Acad Sci U S A 106(25):10171-6 {{SGDpaper|S000130607}} PMID 19520826</ref><ref name='S000052151'>Schlesinger MB and Formosa T (2000) POB3 is required for both transcription and replication in the yeast Saccharomyces cerevisiae. Genetics 155(4):1593-606
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=== Protein Details ===
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==== Protein Modification ====
 
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'''Modification(s)''': Phosphorylation [[Category:Modification:Phosphorylation]]
 
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Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. <ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref> <ref name = 'CAset7903-2004-01-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=7903 Jeff Ubersax] on 2004-01-27</ref>
 
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==Community Commentary==
 
==Community Commentary==
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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==References==
 
==References==
 
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Latest revision as of 07:45, 23 January 2012

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Systematic name YHR164C
Gene name DNA2
Aliases WEB2
Feature type ORF, Verified
Coordinates Chr VIII:429178..424610
Primary SGDID S000001207


Description of YHR164C: Tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization[1][2][3][4][5][6][7]




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Community Commentary

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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [8] [9]




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References

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  1. ↑ Bae SH and Seo YS (2000) Characterization of the enzymatic properties of the yeast dna2 Helicase/endonuclease suggests a new model for Okazaki fragment processing. J Biol Chem 275(48):38022-31 SGD PMID 10984490
  2. ↑ Bae SH, et al. (1998) Dna2 of Saccharomyces cerevisiae possesses a single-stranded DNA-specific endonuclease activity that is able to act on double-stranded DNA in the presence of ATP. J Biol Chem 273(41):26880-90 SGD PMID 9756935
  3. ↑ Balakrishnan L, et al. (2010) Dna2 exhibits a unique strand end-dependent helicase function. J Biol Chem 285(50):38861-8 SGD PMID 20929864
  4. ↑ Budd ME and Campbell JL (1997) A yeast replicative helicase, Dna2 helicase, interacts with yeast FEN-1 nuclease in carrying out its essential function. Mol Cell Biol 17(4):2136-42 SGD PMID 9121462
  5. ↑ Budd ME and Campbell JL (2000) The pattern of sensitivity of yeast dna2 mutants to DNA damaging agents suggests a role in DSB and postreplication repair pathways. Mutat Res 459(3):173-86 SGD PMID 10812329
  6. ↑ Kosugi S, et al. (2009) Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs. Proc Natl Acad Sci U S A 106(25):10171-6 SGD PMID 19520826
  7. ↑ Schlesinger MB and Formosa T (2000) POB3 is required for both transcription and replication in the yeast Saccharomyces cerevisiae. Genetics 155(4):1593-606 SGD PMID 10924459
  8. ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  9. ↑ submitted by Jeff Ubersax on 2004-01-27

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