Difference between revisions of "YHR149C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001192 YHR149C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001192 YHR149C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SKG6 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''SKG6 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr VIII:396662..394458
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|nowrap| Chr VIII:396659..394455
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000001192
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000001192
 
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'''Description of YHR149C:''' Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p<ref name='S000119445'>Tomishige N, et al. (2005) SKG6, a suppressor gene of synthetic lethality of kex2Delta gas1Delta mutations, encodes a novel membrane protein showing polarized intracellular localization. J Gen Appl Microbiol 51(5):323-6 {{SGDpaper|S000119445}} PMID 16314687</ref><ref name='S000080360'>Tomishige N, et al. (2005) SKG1, a suppressor gene of synthetic lethality of kex2Deltagas1Delta mutations, encodes a novel membrane protein that affects cell wall composition. Yeast 22(2):141-55 {{SGDpaper|S000080360}} PMID 15645486</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref><ref name='S000061434'>Drees BL, et al. (2001) A protein interaction map for cell polarity development. J Cell Biol 154(3):549-71
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'''Description of YHR149C:''' Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p<ref name='S000061434'>Drees BL, et al. (2001) A protein interaction map for cell polarity development. J Cell Biol 154(3):549-71 {{SGDpaper|S000061434}} PMID 11489916</ref><ref name='S000080360'>Tomishige N, et al. (2005) SKG1, a suppressor gene of synthetic lethality of kex2Deltagas1Delta mutations, encodes a novel membrane protein that affects cell wall composition. Yeast 22(2):141-55 {{SGDpaper|S000080360}} PMID 15645486</ref><ref name='S000119445'>Tomishige N, et al. (2005) SKG6, a suppressor gene of synthetic lethality of kex2Delta gas1Delta mutations, encodes a novel membrane protein showing polarized intracellular localization. J Gen Appl Microbiol 51(5):323-6 {{SGDpaper|S000119445}} PMID 16314687</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
  {{SGDpaper|S000061434}} PMID 11489916</ref>
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  {{SGDpaper|S000074306}} PMID 14574415</ref>
 
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Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. <ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref> <ref name = 'CAset7903-2004-01-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=7903 Jeff Ubersax] on 2004-01-27</ref>
 
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. <ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref> <ref name = 'CAset7903-2004-01-27'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=7903 Jeff Ubersax] on 2004-01-27</ref>
  
{{ShortCenteredHR}}
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== Transmembrane Domain GxxxG-like motif  ==
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The transmembrane domain of this protein contains GvavAvpvG. The presence of multiple, chained GxxxG-like motifs <ref name='PMID 15313242'> Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242</ref> strongly indicates that Skg6p dimerises.
  
  

Latest revision as of 09:44, 21 March 2013

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Systematic name YHR149C
Gene name SKG6
Aliases
Feature type ORF, Verified
Coordinates Chr VIII:396659..394455
Primary SGDID S000001192


Description of YHR149C: Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p[1][2][3][4]




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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [4] [5]


Transmembrane Domain GxxxG-like motif

The transmembrane domain of this protein contains GvavAvpvG. The presence of multiple, chained GxxxG-like motifs [6] strongly indicates that Skg6p dimerises.




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References

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  1. Drees BL, et al. (2001) A protein interaction map for cell polarity development. J Cell Biol 154(3):549-71 SGD PMID 11489916
  2. Tomishige N, et al. (2005) SKG1, a suppressor gene of synthetic lethality of kex2Deltagas1Delta mutations, encodes a novel membrane protein that affects cell wall composition. Yeast 22(2):141-55 SGD PMID 15645486
  3. Tomishige N, et al. (2005) SKG6, a suppressor gene of synthetic lethality of kex2Delta gas1Delta mutations, encodes a novel membrane protein showing polarized intracellular localization. J Gen Appl Microbiol 51(5):323-6 SGD PMID 16314687
  4. 4.0 4.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415 Cite error: Invalid <ref> tag; name "S000074306" defined multiple times with different content
  5. submitted by Jeff Ubersax on 2004-01-27
  6. Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242

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