Difference between revisions of "YHL035C"

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'''Description of YHL035C:''' Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ATP-binding cassette (ABC) family; potential Cdc28p substrate; detected in purified mitochondria in high-throughput studies<ref name='S000058031'>Decottignies A and Goffeau A (1997) Complete inventory of the yeast ABC proteins. Nat Genet 15(2):137-45 {{SGDpaper|S000058031}} PMID 9020838</ref><ref name='S000115662'>Fleischer TC, et al. (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294-307 {{SGDpaper|S000115662}} PMID 16702403</ref><ref name='S000117178'>Reinders J, et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 {{SGDpaper|S000117178}} PMID 16823961</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
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'''Description of YHL035C:''' Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions<ref name='S000058031'>Decottignies A and Goffeau A (1997) Complete inventory of the yeast ABC proteins. Nat Genet 15(2):137-45 {{SGDpaper|S000058031}} PMID 9020838</ref><ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref><ref name='S000136455'>Wawrzycka D, et al. (2010) Vmr 1p is a novel vacuolar multidrug resistance ABC transporter in Saccharomyces cerevisiae. FEMS Yeast Res 10(7):828-38
  {{SGDpaper|S000074306}} PMID 14574415</ref>
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  {{SGDpaper|S000136455}} PMID 20846144</ref>
 
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Revision as of 14:05, 25 January 2011

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Systematic name YHL035C
Gene name VMR1
Aliases
Feature type ORF, Verified
Coordinates Chr VIII:32754..27976
Primary SGDID S000001027


Description of YHL035C: Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions[1][2][3]




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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [2] [4]





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References

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  1. Decottignies A and Goffeau A (1997) Complete inventory of the yeast ABC proteins. Nat Genet 15(2):137-45 SGD PMID 9020838
  2. 2.0 2.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  3. Wawrzycka D, et al. (2010) Vmr 1p is a novel vacuolar multidrug resistance ABC transporter in Saccharomyces cerevisiae. FEMS Yeast Res 10(7):828-38 SGD PMID 20846144
  4. submitted by Jeff Ubersax on 2004-01-27

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