Difference between revisions of "YHL023C"

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'''Description of YHL023C:''' Component, with Npr2p, of an evolutionarily conserved complex that mediates downregulation of TOR Complex 1 activity in response to amino acid limitation; null mutant displays delayed meiotic DNA replication and double-strand break repair<ref name='S000072583'>Enyenihi AH and Saunders WS (2003) Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae. Genetics 163(1):47-54 {{SGDpaper|S000072583}} PMID 12586695</ref><ref name='S000124986'>Jordan PW, et al. (2007) Novel roles for selected genes in meiotic DNA processing. PLoS Genet 3(12):e222 {{SGDpaper|S000124986}} PMID 18069899</ref><ref name='S000130605'>Neklesa TK and Davis RW (2009) A Genome-Wide Screen for Regulators of TORC1 in Response to Amino Acid Starvation Reveals a Conserved Npr2/3 Complex. PLoS Genet 5(6):e1000515
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'''Description of YHL023C:''' Subunit of the conserved Npr2/3 complex that mediates downregulation of TORC1 activity upon amino acid limitation; subunit of SEA (Seh1-associated) complex; null mutant displays delayed meiotic DNA replication and double-strand break repair<ref name='S000144831'>Dokudovskaya S, et al. (2011) A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. Mol Cell Proteomics () {{SGDpaper|S000144831}} PMID 21454883</ref><ref name='S000072583'>Enyenihi AH and Saunders WS (2003) Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae. Genetics 163(1):47-54 {{SGDpaper|S000072583}} PMID 12586695</ref><ref name='S000124986'>Jordan PW, et al. (2007) Novel roles for selected genes in meiotic DNA processing. PLoS Genet 3(12):e222 {{SGDpaper|S000124986}} PMID 18069899</ref><ref name='S000130605'>Neklesa TK and Davis RW (2009) A Genome-Wide Screen for Regulators of TORC1 in Response to Amino Acid Starvation Reveals a Conserved Npr2/3 Complex. PLoS Genet 5(6):e1000515
 
  {{SGDpaper|S000130605}} PMID 19521502</ref>
 
  {{SGDpaper|S000130605}} PMID 19521502</ref>
 
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Revision as of 14:05, 6 April 2011

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Systematic name YHL023C
Gene name NPR3
Aliases RMD11
Feature type ORF, Verified
Coordinates Chr VIII:62563..59123
Primary SGDID S000001015


Description of YHL023C: Subunit of the conserved Npr2/3 complex that mediates downregulation of TORC1 activity upon amino acid limitation; subunit of SEA (Seh1-associated) complex; null mutant displays delayed meiotic DNA replication and double-strand break repair[1][2][3][4]




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References

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  1. Dokudovskaya S, et al. (2011) A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. Mol Cell Proteomics () SGD PMID 21454883
  2. Enyenihi AH and Saunders WS (2003) Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae. Genetics 163(1):47-54 SGD PMID 12586695
  3. Jordan PW, et al. (2007) Novel roles for selected genes in meiotic DNA processing. PLoS Genet 3(12):e222 SGD PMID 18069899
  4. Neklesa TK and Davis RW (2009) A Genome-Wide Screen for Regulators of TORC1 in Response to Amino Acid Starvation Reveals a Conserved Npr2/3 Complex. PLoS Genet 5(6):e1000515 SGD PMID 19521502

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