Difference between revisions of "YGR232W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003464 YGR232W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''NAS6 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''NAS6 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr VII: | + | |nowrap| Chr VII:953960..954646 |
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003464 | ||
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| − | '''Description of | + | '''Description of YGR232W:''' Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6<ref name='S000130402'>Funakoshi M, et al. (2009) Multiple assembly chaperones govern biogenesis of the proteasome regulatory particle base. Cell 137(5):887-99 {{SGDpaper|S000130402}} PMID 19446322</ref><ref name='S000053107'>Hori T, et al. (1998) cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome. Gene 216(1):113-22 {{SGDpaper|S000053107}} PMID 9714768</ref><ref name='S000079321'>Padmanabhan B, et al. (2004) Crystal structure of the homolog of the oncoprotein gankyrin, an interactor of Rb and CDK4/6. J Biol Chem 279(2):1546-52 {{SGDpaper|S000079321}} PMID 14583612</ref><ref name='S000130205'>Roelofs J, et al. (2009) Chaperone-mediated pathway of proteasome regulatory particle assembly. Nature 459(7248):861-5 {{SGDpaper|S000130205}} PMID 19412159</ref><ref name='S000130401'>Saeki Y, et al. (2009) Multiple proteasome-interacting proteins assist the assembly of the yeast 19S regulatory particle. Cell 137(5):900-13 |
| − | {{SGDpaper| | + | {{SGDpaper|S000130401}} PMID 19446323</ref> |
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==Community Commentary== | ==Community Commentary== | ||
{{CommentaryHelp}} | {{CommentaryHelp}} | ||
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| + | <!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation --> | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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Latest revision as of 07:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YGR232W |
| Gene name | NAS6 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:953960..954646 |
| Primary SGDID | S000003464 |
Description of YGR232W: Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6[1][2][3][4][5]
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References
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- ↑ Funakoshi M, et al. (2009) Multiple assembly chaperones govern biogenesis of the proteasome regulatory particle base. Cell 137(5):887-99 SGD PMID 19446322
- ↑ Hori T, et al. (1998) cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome. Gene 216(1):113-22 SGD PMID 9714768
- ↑ Padmanabhan B, et al. (2004) Crystal structure of the homolog of the oncoprotein gankyrin, an interactor of Rb and CDK4/6. J Biol Chem 279(2):1546-52 SGD PMID 14583612
- ↑ Roelofs J, et al. (2009) Chaperone-mediated pathway of proteasome regulatory particle assembly. Nature 459(7248):861-5 SGD PMID 19412159
- ↑ Saeki Y, et al. (2009) Multiple proteasome-interacting proteins assist the assembly of the yeast 19S regulatory particle. Cell 137(5):900-13 SGD PMID 19446323
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