Difference between revisions of "YGR232W"

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'''Description of YGR232W:''' Protein involved in the assembly of the proteasome regulatory particle (RP); homolog of the human oncoprotein gankyrin, which interacts with the retinoblastoma tumor suppressor (Rb) and cyclin-dependent kinase 4/6<ref name='S000053107'>Hori T, et al. (1998) cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome. Gene 216(1):113-22 {{SGDpaper|S000053107}} PMID 9714768</ref><ref name='S000079321'>Padmanabhan B, et al. (2004) Crystal structure of the homolog of the oncoprotein gankyrin, an interactor of Rb and CDK4/6. J Biol Chem 279(2):1546-52 {{SGDpaper|S000079321}} PMID 14583612</ref><ref name='S000130205'>Roelofs J, et al. (2009) Chaperone-mediated pathway of proteasome regulatory particle assembly. Nature
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'''Description of YGR232W:''' Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6<ref name='S000053107'>Hori T, et al. (1998) cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome. Gene 216(1):113-22 {{SGDpaper|S000053107}} PMID 9714768</ref><ref name='S000079321'>Padmanabhan B, et al. (2004) Crystal structure of the homolog of the oncoprotein gankyrin, an interactor of Rb and CDK4/6. J Biol Chem 279(2):1546-52 {{SGDpaper|S000079321}} PMID 14583612</ref><ref name='S000130401'>Saeki Y, et al. (2009) Multiple Proteasome-Interacting Proteins Assist the Assembly of the Yeast 19S Regulatory Particle. Cell {{SGDpaper|S000130401}} PMID 19446323</ref><ref name='S000130402'>Funakoshi M, et al. (2009) Multiple Assembly Chaperones Govern Biogenesis of the Proteasome Regulatory Particle Base. Cell {{SGDpaper|S000130402}} PMID 19446322</ref><ref name='S000130205'>Roelofs J, et al. (2009) Chaperone-mediated pathway of proteasome regulatory particle assembly. Nature
 
  {{SGDpaper|S000130205}} PMID 19412159</ref>
 
  {{SGDpaper|S000130205}} PMID 19412159</ref>
 
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Revision as of 14:05, 4 June 2009

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Systematic name YGR232W
Gene name NAS6
Aliases
Feature type ORF, Verified
Coordinates Chr VII:953963..954649
Primary SGDID S000003464


Description of YGR232W: Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6[1][2][3][4][5]




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References

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  1. Hori T, et al. (1998) cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome. Gene 216(1):113-22 SGD PMID 9714768
  2. Padmanabhan B, et al. (2004) Crystal structure of the homolog of the oncoprotein gankyrin, an interactor of Rb and CDK4/6. J Biol Chem 279(2):1546-52 SGD PMID 14583612
  3. Saeki Y, et al. (2009) Multiple Proteasome-Interacting Proteins Assist the Assembly of the Yeast 19S Regulatory Particle. Cell SGD PMID 19446323
  4. Funakoshi M, et al. (2009) Multiple Assembly Chaperones Govern Biogenesis of the Proteasome Regulatory Particle Base. Cell SGD PMID 19446322
  5. Roelofs J, et al. (2009) Chaperone-mediated pathway of proteasome regulatory particle assembly. Nature SGD PMID 19412159

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