YGR222W

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Systematic name YGR222W
Gene name PET54
Aliases
Feature type ORF, Verified
Coordinates Chr VII:939926..940807
Primary SGDID S000003454


Description of YGR222W: Protein required for splicing of the COX1 intron AI5 beta; also specifically required, together with Pet122p and Pet494p, for translation of the COX3 mRNA; located in the mitochondrial inner membrane[1][2][3]




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Community Commentary

Pet54 is imported into mitochondria without amino-terminal processing. McMullin TW, Fox TD (1993) COX3 mRNA-specific translational activator proteins are associated with the inner mitochondrial membrane in Saccharomyces cerevisiae. J Biol Chem 268(16):11737-41.




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References

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  1. Naithani S, et al. (2003) Interactions among COX1, COX2, and COX3 mRNA-specific translational activator proteins on the inner surface of the mitochondrial inner membrane of Saccharomyces cerevisiae. Mol Biol Cell 14(1):324-33 SGD PMID 12529447
  2. Costanzo MC, et al. (1989) The PET54 gene of Saccharomyces cerevisiae: characterization of a nuclear gene encoding a mitochondrial translational activator and subcellular localization of its product. Genetics 122(2):297-305 SGD PMID 2548921
  3. Valencik ML, et al. (1989) Disruption of the yeast nuclear PET54 gene blocks excision of mitochondrial intron aI5 beta from pre-mRNA for cytochrome c oxidase subunit I. EMBO J 8(12):3899-904 SGD PMID 2555177

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