Difference between revisions of "YGR222W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003454 YGR222W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003454 YGR222W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''PET54 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''PET54 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr VII:939926..940807
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|nowrap| Chr VII:939923..940804
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000003454
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000003454
 
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'''Description of YGR222W:''' Protein required for splicing of the COX1 intron AI5 beta; also specifically required, together with Pet122p and Pet494p, for translation of the COX3 mRNA; located in the mitochondrial inner membrane<ref name='S000072504'>Naithani S, et al. (2003) Interactions among COX1, COX2, and COX3 mRNA-specific translational activator proteins on the inner surface of the mitochondrial inner membrane of Saccharomyces cerevisiae. Mol Biol Cell 14(1):324-33 {{SGDpaper|S000072504}} PMID 12529447</ref><ref name='S000054211'>Costanzo MC, et al. (1989) The PET54 gene of Saccharomyces cerevisiae: characterization of a nuclear gene encoding a mitochondrial translational activator and subcellular localization of its product. Genetics 122(2):297-305 {{SGDpaper|S000054211}} PMID 2548921</ref><ref name='S000047957'>Valencik ML, et al. (1989) Disruption of the yeast nuclear PET54 gene blocks excision of mitochondrial intron aI5 beta from pre-mRNA for cytochrome c oxidase subunit I. EMBO J 8(12):3899-904
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'''Description of YGR222W:''' Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing<ref name='S000054211'>Costanzo MC, et al. (1989) The PET54 gene of Saccharomyces cerevisiae: characterization of a nuclear gene encoding a mitochondrial translational activator and subcellular localization of its product. Genetics 122(2):297-305 {{SGDpaper|S000054211}} PMID 2548921</ref><ref name='S000125994'>Kaspar BJ, et al. (2008) A shared RNA-binding site in the Pet54 protein is required for translational activation and group I intron splicing in yeast mitochondria. Nucleic Acids Res 36(9):2958-68 {{SGDpaper|S000125994}} PMID 18388132</ref><ref name='S000072504'>Naithani S, et al. (2003) Interactions among COX1, COX2, and COX3 mRNA-specific translational activator proteins on the inner surface of the mitochondrial inner membrane of Saccharomyces cerevisiae. Mol Biol Cell 14(1):324-33 {{SGDpaper|S000072504}} PMID 12529447</ref><ref name='S000047957'>Valencik ML, et al. (1989) Disruption of the yeast nuclear PET54 gene blocks excision of mitochondrial intron aI5 beta from pre-mRNA for cytochrome c oxidase subunit I. EMBO J 8(12):3899-904
 
  {{SGDpaper|S000047957}} PMID 2555177</ref>
 
  {{SGDpaper|S000047957}} PMID 2555177</ref>
 
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==Community Commentary==
 
==Community Commentary==
Pet54 is imported into mitochondria without amino-terminal processing.  McMullin TW, Fox TD (1993) COX3 mRNA-specific translational activator proteins are associated with the inner mitochondrial membrane in Saccharomyces cerevisiae. J Biol Chem 268(16):11737-41.
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
 
<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
 
J Biol Chem 278(5):3265-74</ref>
 
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==References==
 
==References==
 
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Latest revision as of 07:45, 23 January 2012

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Systematic name YGR222W
Gene name PET54
Aliases
Feature type ORF, Verified
Coordinates Chr VII:939923..940804
Primary SGDID S000003454


Description of YGR222W: Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing[1][2][3][4]




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References

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  1. Costanzo MC, et al. (1989) The PET54 gene of Saccharomyces cerevisiae: characterization of a nuclear gene encoding a mitochondrial translational activator and subcellular localization of its product. Genetics 122(2):297-305 SGD PMID 2548921
  2. Kaspar BJ, et al. (2008) A shared RNA-binding site in the Pet54 protein is required for translational activation and group I intron splicing in yeast mitochondria. Nucleic Acids Res 36(9):2958-68 SGD PMID 18388132
  3. Naithani S, et al. (2003) Interactions among COX1, COX2, and COX3 mRNA-specific translational activator proteins on the inner surface of the mitochondrial inner membrane of Saccharomyces cerevisiae. Mol Biol Cell 14(1):324-33 SGD PMID 12529447
  4. Valencik ML, et al. (1989) Disruption of the yeast nuclear PET54 gene blocks excision of mitochondrial intron aI5 beta from pre-mRNA for cytochrome c oxidase subunit I. EMBO J 8(12):3899-904 SGD PMID 2555177

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