Difference between revisions of "YGR155W"
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| − | '''Description of YGR155W:''' Cystathionine beta-synthase, catalyzes | + | '''Description of YGR155W:''' Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; mutations in human ortholog cause homocystinuria<ref name='S000042385'>Ono B, et al. (1994) Purification and properties of Saccharomyces cerevisiae cystathionine beta-synthase. Yeast 10(3):333-9 {{SGDpaper|S000042385}} PMID 8017103</ref><ref name='S000052237'>Ono B, et al. (1988) Cysteine biosynthesis in Saccharomyces cerevisiae: mutation that confers cystathionine beta-synthase deficiency. J Bacteriol 170(12):5883-9 {{SGDpaper|S000052237}} PMID 3056921</ref><ref name='S000062636'>Shan X and Kruger WD (1998) Correction of disease-causing CBS mutations in yeast. Nat Genet 19(1):91-3 {{SGDpaper|S000062636}} PMID 9590298</ref><ref name='S000130695'>Singh S, et al. (2009) The relative contributions of cystathionine beta-synthase and gamma-cystathionase to H2S biogenesis via alternative transsulfuration reactions. J Biol Chem |
| − | {{SGDpaper| | + | {{SGDpaper|S000130695}} PMID 19531479</ref> |
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Revision as of 14:05, 7 August 2009
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| Systematic name | YGR155W |
| Gene name | CYS4 |
| Aliases | NHS5, STR4, VMA41 |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:798548..800071 |
| Primary SGDID | S000003387 |
Description of YGR155W: Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; mutations in human ortholog cause homocystinuria[1][2][3][4]
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References
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- ↑ Ono B, et al. (1994) Purification and properties of Saccharomyces cerevisiae cystathionine beta-synthase. Yeast 10(3):333-9 SGD PMID 8017103
- ↑ Ono B, et al. (1988) Cysteine biosynthesis in Saccharomyces cerevisiae: mutation that confers cystathionine beta-synthase deficiency. J Bacteriol 170(12):5883-9 SGD PMID 3056921
- ↑ Shan X and Kruger WD (1998) Correction of disease-causing CBS mutations in yeast. Nat Genet 19(1):91-3 SGD PMID 9590298
- ↑ Singh S, et al. (2009) The relative contributions of cystathionine beta-synthase and gamma-cystathionase to H2S biogenesis via alternative transsulfuration reactions. J Biol Chem SGD PMID 19531479
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