YGR150C

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Systematic name YGR150C
Gene name CCM1
Aliases DMR1, RRG2
Feature type ORF, Verified
Coordinates Chr VII:793058..790464
Primary SGDID S000003382


Description of YGR150C: Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport[1][2][3][4][5][6][7]




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References

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  1. Dimmer KS, et al. (2002) Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol Biol Cell 13(3):847-53 SGD PMID 11907266
  2. Ellis TP, et al. (2004) Aep3p stabilizes the mitochondrial bicistronic mRNA encoding subunits 6 and 8 of the H+-translocating ATP synthase of Saccharomyces cerevisiae. J Biol Chem 279(16):15728-33 SGD PMID 14742425
  3. Herst PM, et al. (2008) Plasma membrane electron transport in Saccharomyces cerevisiae depends on the presence of mitochondrial respiratory subunits. FEMS Yeast Res 8(6):897-905 SGD PMID 18657191
  4. Moreno JI, et al. (2009) Ccm1p/Ygr150cp, a pentatricopeptide repeat protein, is essential to remove the fourth intron of both COB and COX1 pre-mRNAs in Saccharomyces cerevisiae. Curr Genet 55(4):475-84 SGD PMID 19562342
  5. Puchta O, et al. (2010) DMR1 (CCM1/YGR150C) of Saccharomyces cerevisiae Encodes an RNA-Binding Protein from the Pentatricopeptide Repeat Family Required for the Maintenance of the Mitochondrial 15S Ribosomal RNA. Genetics () SGD PMID 20124025
  6. Reinders J, et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD PMID 16823961
  7. Steinmetz LM, et al. (2002) Systematic screen for human disease genes in yeast. Nat Genet 31(4):400-4 SGD PMID 12134146

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