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Systematic name YGR146C
Gene name ECL1
Feature type ORF, Verified
Coordinates Chr VII:784858..784223
Primary SGDID S000003378

Description of YGR146C: Protein of unknown function; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results in reduced oxygen consumption under conditions of caloric restriction; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation[1][2][3][4][5]


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DNA and RNA Details

Other DNA and RNA Details

Other Topic: expression

Specifically lower expression in nitrogen limited chemostat cultures versus nitrogen excess. [6] [7]



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  1. Azuma K, et al. (2009) Identification and Characterization of an Ecl1-Family Gene in Saccharomyces cerevisiae. Biosci Biotechnol Biochem 73(12):2787-9 SGD PMID 19966476
  2. Azuma K, et al. (2012) Extension of Chronological Lifespan by ScEcl1 Depends on the Mitochondria in Saccharomyces cerevisiae. Biosci Biotechnol Biochem () SGD PMID 23047113
  3. Dardalhon M, et al. (2007) Specific transcriptional responses induced by 8-methoxypsoralen and UVA in yeast. FEMS Yeast Res 7(6):866-878 SGD PMID 17608707
  4. Imazu H and Sakurai H (2005) Saccharomyces cerevisiae heat shock transcription factor regulates cell wall remodeling in response to heat shock. Eukaryot Cell 4(6):1050-6 SGD PMID 15947197
  5. Rutherford JC, et al. (2003) Aft1p and Aft2p mediate iron-responsive gene expression in yeast through related promoter elements. J Biol Chem 278(30):27636-43 SGD PMID 12756250
  6. Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
  7. submitted by Viktor Boer on 2003-07-25

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