Difference between revisions of "YGR062C"

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'''Description of YGR062C:''' Mitochondrial inner membrane protein, required for export of the Cox2p C terminus from the mitochondrial matrix to the intermembrane space during its assembly into cytochrome c oxidase; similar to Oxa2p of N. crassa<ref name='S000069749'>Saracco SA and Fox TD (2002) Cox18p is required for export of the mitochondrially encoded Saccharomyces cerevisiae Cox2p C-tail and interacts with Pnt1p and Mss2p in the inner membrane. Mol Biol Cell 13(4):1122-31
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'''Description of YGR062C:''' Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC<ref name='S000124372'>van Bloois E, et al. (2007) Saccharomyces cerevisiae Cox18 complements the essential Sec-independent function of Escherichia coli YidC. FEBS J 274(21):5704-13 {{SGDpaper|S000124372}} PMID 17922846</ref><ref name='S000122409'>Fiumera HL, et al. (2007) Translocation of mitochondrially synthesized Cox2 domains from the matrix to the intermembrane space. Mol Cell Biol 27(13):4664-73 {{SGDpaper|S000122409}} PMID 17452441</ref><ref name='S000069749'>Saracco SA and Fox TD (2002) Cox18p is required for export of the mitochondrially encoded Saccharomyces cerevisiae Cox2p C-tail and interacts with Pnt1p and Mss2p in the inner membrane. Mol Biol Cell 13(4):1122-31 {{SGDpaper|S000069749}} PMID 11950926</ref><ref name='S000050027'>Souza RL, et al. (2000) Cloning and characterization of COX18, a Saccharomyces cerevisiae PET gene required for the assembly of cytochrome oxidase. J Biol Chem 275(20):14898-902
  {{SGDpaper|S000069749}} PMID 11950926</ref>
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  {{SGDpaper|S000050027}} PMID 10809734</ref>
 
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Revision as of 14:05, 1 February 2008

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Systematic name YGR062C
Gene name COX18
Aliases OXA2
Feature type ORF, Verified
Coordinates Chr VII:617282..616332
Primary SGDID S000003294


Description of YGR062C: Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC[1][2][3][4]




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References

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  1. van Bloois E, et al. (2007) Saccharomyces cerevisiae Cox18 complements the essential Sec-independent function of Escherichia coli YidC. FEBS J 274(21):5704-13 SGD PMID 17922846
  2. Fiumera HL, et al. (2007) Translocation of mitochondrially synthesized Cox2 domains from the matrix to the intermembrane space. Mol Cell Biol 27(13):4664-73 SGD PMID 17452441
  3. Saracco SA and Fox TD (2002) Cox18p is required for export of the mitochondrially encoded Saccharomyces cerevisiae Cox2p C-tail and interacts with Pnt1p and Mss2p in the inner membrane. Mol Biol Cell 13(4):1122-31 SGD PMID 11950926
  4. Souza RL, et al. (2000) Cloning and characterization of COX18, a Saccharomyces cerevisiae PET gene required for the assembly of cytochrome oxidase. J Biol Chem 275(20):14898-902 SGD PMID 10809734

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