Difference between revisions of "YGR014W"

From SGD-Wiki
Jump to: navigation, search
(Automated import of articles)
 
(3 intermediate revisions by 2 users not shown)
Line 4: Line 4:
 
{|{{Prettytable}} align = 'right' width = '200px'
 
{|{{Prettytable}} align = 'right' width = '200px'
 
|-
 
|-
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003246 YGR014W]  
+
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003246 YGR014W]  
 
|-
 
|-
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''MSB2 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''MSB2 ''
Line 29: Line 29:
 
==Community Commentary==
 
==Community Commentary==
 
{{CommentaryHelp}}
 
{{CommentaryHelp}}
 +
== Transmembrane Domain GxxxG  ==
 +
 +
The transmembrane domain of Msb2 shows homology with the SKG6/AXL2 alpha-helix transmembrane domain (IPR014805). In particular, this domain begins with iiGlviGvvvG. The presence of two, overlapping GxxxG motifs <ref name='PMID 15313242'> Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242</ref> strongly indicates that Msb2 dimerises.
 +
 +
 
=== Protein Details ===
 
=== Protein Details ===
 
[[Category:Topic:Protein Details]]
 
[[Category:Topic:Protein Details]]

Latest revision as of 09:32, 21 March 2013

Share your knowledge...Edit this entry! <protect>

Systematic name YGR014W
Gene name MSB2
Aliases
Feature type ORF, Verified
Coordinates Chr VII:516943..520863
Primary SGDID S000003246


Description of YGR014W: Mucin family member involved in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate[1][2][3][4]




</protect>

Community Commentary

About Community Commentary. Please share your knowledge!

Transmembrane Domain GxxxG

The transmembrane domain of Msb2 shows homology with the SKG6/AXL2 alpha-helix transmembrane domain (IPR014805). In particular, this domain begins with iiGlviGvvvG. The presence of two, overlapping GxxxG motifs [5] strongly indicates that Msb2 dimerises.


Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [4] [6]





<protect>

References

See Help:References on how to add references

  1. Bender A and Pringle JR (1989) Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1. Proc Natl Acad Sci U S A 86(24):9976-80 SGD PMID 2690082
  2. Cullen PJ, et al. (2004) A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast. Genes Dev 18(14):1695-708 SGD PMID 15256499
  3. O'Rourke SM and Herskowitz I (2002) A third osmosensing branch in Saccharomyces cerevisiae requires the Msb2 protein and functions in parallel with the Sho1 branch. Mol Cell Biol 22(13):4739-49 SGD PMID 12052881
  4. 4.0 4.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415 Cite error: Invalid <ref> tag; name "S000074306" defined multiple times with different content
  5. Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242
  6. submitted by Jeff Ubersax on 2004-01-27

See Help:Categories on how to add the wiki page for this gene to a Category </protect>