YGR003W

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Systematic name YGR003W
Gene name CUL3
Aliases CULB
Feature type ORF, Verified
Coordinates Chr VII:500132..502366
Primary SGDID S000003235


Description of YGR003W: Ubiquitin-protein ligase, member of the cullin family with similarity to Cdc53p and human CUL3; required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21[1][2][3]




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References

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  1. Lammer D, et al. (1998) Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex. Genes Dev 12(7):914-26 SGD PMID 9531531
  2. Michel JJ, et al. (2003) A role for Saccharomyces cerevisiae Cul8 ubiquitin ligase in proper anaphase progression. J Biol Chem 278(25):22828-37 SGD PMID 12676951
  3. Ribar B, et al. (2007) ELA1 and CUL3 are required along with ELC1 for RNA polymerase II polyubiquitylation and degradation in DNA-damaged yeast cells. Mol Cell Biol 27(8):3211-6 SGD PMID 17296727

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