Difference between revisions of "YGL235W"

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In a BY4735 background, knocking out YGL235W seems to have a moderate effect on growth rate in log-phase.  In this assay, the BY4735 strain's doubling time was 124 minutes, while the YGL235W knock-out strain's doubling time was 209 minutes.  
 
In a BY4735 background, knocking out YGL235W seems to have a moderate effect on growth rate in log-phase.  In this assay, the BY4735 strain's doubling time was 124 minutes, while the YGL235W knock-out strain's doubling time was 209 minutes.  
  
 
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J Biol Chem 278(5):3265-74</ref>
 
J Biol Chem 278(5):3265-74</ref>
 
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==References==
 
==References==
 
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Revision as of 07:59, 30 April 2019

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Systematic name YGL235W
Gene name
Aliases
Feature type ORF, Uncharacterized
Coordinates Chr VII:55279..55815
Primary SGDID S000003204


Description of YGL235W: Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2[1][2]




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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [2] [3]



This gene is part of the UW-Stout Orphan Gene Project. Learn more here.

Growth Curve

ygl235w growth.png

In a BY4735 background, knocking out YGL235W seems to have a moderate effect on growth rate in log-phase. In this assay, the BY4735 strain's doubling time was 124 minutes, while the YGL235W knock-out strain's doubling time was 209 minutes.

image003.png


References

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  1. Chamilos G, et al. (2008) Genomewide Screening for Genes Associated with Gliotoxin Resistance and Sensitivity in Saccharomyces cerevisiae. Antimicrob Agents Chemother 52(4):1325-9 SGD PMID 18212113
  2. 2.0 2.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415 Cite error: Invalid <ref> tag; name "S000074306" defined multiple times with different content
  3. submitted by Jeff Ubersax on 2004-01-27

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