Difference between revisions of "YGL190C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003158 YGL190C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''CDC55 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''CDC55 '' | ||
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| − | '''Description of YGL190C:''' Non-essential regulatory subunit B of protein phosphatase 2A (PP2A) | + | '''Description of YGL190C:''' Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion<ref name='S000145793'>Bizzari F and Marston AL (2011) Cdc55 coordinates spindle assembly and chromosome disjunction during meiosis. J Cell Biol () {{SGDpaper|S000145793}} PMID 21690308</ref><ref name='S000071578'>Gentry MS and Hallberg RL (2002) Localization of Saccharomyces cerevisiae protein phosphatase 2A subunits throughout mitotic cell cycle. Mol Biol Cell 13(10):3477-92 {{SGDpaper|S000071578}} PMID 12388751</ref><ref name='S000045742'>Jiang Y and Broach JR (1999) Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast. EMBO J 18(10):2782-92 {{SGDpaper|S000045742}} PMID 10329624</ref><ref name='S000116004'>Queralt E, et al. (2006) Downregulation of PP2A(Cdc55) phosphatase by separase initiates mitotic exit in budding yeast. Cell 125(4):719-32 {{SGDpaper|S000116004}} PMID 16713564</ref><ref name='S000145282'>Rossio V and Yoshida S (2011) Spatial regulation of Cdc55-PP2A by Zds1/Zds2 controls mitotic entry and mitotic exit in budding yeast. J Cell Biol 193(3):445-54 {{SGDpaper|S000145282}} PMID 21536748</ref><ref name='S000055155'>Wang Y and Burke DJ (1997) Cdc55p, the B-type regulatory subunit of protein phosphatase 2A, has multiple functions in mitosis and is required for the kinetochore/spindle checkpoint in Saccharomyces cerevisiae. Mol Cell Biol 17(2):620-6 |
{{SGDpaper|S000055155}} PMID 9001215</ref> | {{SGDpaper|S000055155}} PMID 9001215</ref> | ||
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Latest revision as of 14:05, 26 January 2012
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| Systematic name | YGL190C |
| Gene name | CDC55 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:147389..145809 |
| Primary SGDID | S000003158 |
Description of YGL190C: Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion[1][2][3][4][5][6]
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References
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- ↑ Bizzari F and Marston AL (2011) Cdc55 coordinates spindle assembly and chromosome disjunction during meiosis. J Cell Biol () SGD PMID 21690308
- ↑ Gentry MS and Hallberg RL (2002) Localization of Saccharomyces cerevisiae protein phosphatase 2A subunits throughout mitotic cell cycle. Mol Biol Cell 13(10):3477-92 SGD PMID 12388751
- ↑ Jiang Y and Broach JR (1999) Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast. EMBO J 18(10):2782-92 SGD PMID 10329624
- ↑ Queralt E, et al. (2006) Downregulation of PP2A(Cdc55) phosphatase by separase initiates mitotic exit in budding yeast. Cell 125(4):719-32 SGD PMID 16713564
- ↑ Rossio V and Yoshida S (2011) Spatial regulation of Cdc55-PP2A by Zds1/Zds2 controls mitotic entry and mitotic exit in budding yeast. J Cell Biol 193(3):445-54 SGD PMID 21536748
- ↑ Wang Y and Burke DJ (1997) Cdc55p, the B-type regulatory subunit of protein phosphatase 2A, has multiple functions in mitosis and is required for the kinetochore/spindle checkpoint in Saccharomyces cerevisiae. Mol Cell Biol 17(2):620-6 SGD PMID 9001215
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