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Systematic name YGL173C
Gene name XRN1
Aliases DST2, KEM1, RAR5, SEP1, SKI1
Feature type ORF, Verified
Coordinates Chr VII:180113..175527
Primary SGDID S000003141

Description of YGL173C: Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance; activated by the scavenger decapping enzyme Dcs1p[1][2][3][4][5][6][7]


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  1. Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 SGD PMID 15161972
  2. Geerlings TH, et al. (2000) The final step in the formation of 25S rRNA in Saccharomyces cerevisiae is performed by 5'-->3' exonucleases. RNA 6(12):1698-703 SGD PMID 11142370
  3. Kim J and Kim J (2002) KEM1 is involved in filamentous growth of Saccharomyces cerevisiae. FEMS Microbiol Lett 216(1):33-8 SGD PMID 12423748
  4. Larimer FW and Stevens A (1990) Disruption of the gene XRN1, coding for a 5'----3' exoribonuclease, restricts yeast cell growth. Gene 95(1):85-90 SGD PMID 1979303
  5. Sheth U and Parker R (2003) Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300(5620):805-8 SGD PMID 12730603
  6. Sinturel F, et al. (2012) Activation of 5'-3' exoribonuclease Xrn1 by cofactor Dcs1 is essential for mitochondrial function in yeast. Proc Natl Acad Sci U S A () SGD PMID 22570495
  7. Solinger JA, et al. (1999) Active-site mutations in the Xrn1p exoribonuclease of Saccharomyces cerevisiae reveal a specific role in meiosis. Mol Cell Biol 19(9):5930-42 SGD PMID 10454540

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