Difference between revisions of "YGL173C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003141 YGL173C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003141 YGL173C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''KEM1 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''XRN1 ''
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''          ||''DST2, RAR5, SEP1, SKI1, XRN1''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Aliases'''          ||''DST2, KEM1, RAR5, SEP1, SKI1''
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''          || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Feature type'''          || ORF, Verified[[Category:ORF]][[Category:ORF, Verified]]
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'''Description of YGL173C:''' Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance<ref name='S000114270'>Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 {{SGDpaper|S000114270}} PMID 15161972</ref><ref name='S000059142'>Geerlings TH, et al. (2000) The final step in the formation of 25S rRNA in Saccharomyces cerevisiae is performed by 5'-->3' exonucleases. RNA 6(12):1698-703 {{SGDpaper|S000059142}} PMID 11142370</ref><ref name='S000071615'>Kim J and Kim J (2002) KEM1 is involved in filamentous growth of Saccharomyces cerevisiae. FEMS Microbiol Lett 216(1):33-8 {{SGDpaper|S000071615}} PMID 12423748</ref><ref name='S000073211'>Sheth U and Parker R (2003) Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300(5620):805-8 {{SGDpaper|S000073211}} PMID 12730603</ref><ref name='S000052508'>Solinger JA, et al. (1999) Active-site mutations in the Xrn1p exoribonuclease of Saccharomyces cerevisiae reveal a specific role in meiosis. Mol Cell Biol 19(9):5930-42
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'''Description of YGL173C:''' Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance; activated by the scavenger decapping enzyme Dcs1p<ref name='S000114270'>Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 {{SGDpaper|S000114270}} PMID 15161972</ref><ref name='S000059142'>Geerlings TH, et al. (2000) The final step in the formation of 25S rRNA in Saccharomyces cerevisiae is performed by 5'-->3' exonucleases. RNA 6(12):1698-703 {{SGDpaper|S000059142}} PMID 11142370</ref><ref name='S000071615'>Kim J and Kim J (2002) KEM1 is involved in filamentous growth of Saccharomyces cerevisiae. FEMS Microbiol Lett 216(1):33-8 {{SGDpaper|S000071615}} PMID 12423748</ref><ref name='S000041422'>Larimer FW and Stevens A (1990) Disruption of the gene XRN1, coding for a 5'----3' exoribonuclease, restricts yeast cell growth. Gene 95(1):85-90 {{SGDpaper|S000041422}} PMID 1979303</ref><ref name='S000073211'>Sheth U and Parker R (2003) Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300(5620):805-8 {{SGDpaper|S000073211}} PMID 12730603</ref><ref name='S000149451'>Sinturel F, et al. (2012) Activation of 5'-3' exoribonuclease Xrn1 by cofactor Dcs1 is essential for mitochondrial function in yeast. Proc Natl Acad Sci U S A () {{SGDpaper|S000149451}} PMID 22570495</ref><ref name='S000052508'>Solinger JA, et al. (1999) Active-site mutations in the Xrn1p exoribonuclease of Saccharomyces cerevisiae reveal a specific role in meiosis. Mol Cell Biol 19(9):5930-42
 
  {{SGDpaper|S000052508}} PMID 10454540</ref>
 
  {{SGDpaper|S000052508}} PMID 10454540</ref>
 
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Latest revision as of 14:05, 18 June 2012

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Systematic name YGL173C
Gene name XRN1
Aliases DST2, KEM1, RAR5, SEP1, SKI1
Feature type ORF, Verified
Coordinates Chr VII:180113..175527
Primary SGDID S000003141


Description of YGL173C: Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance; activated by the scavenger decapping enzyme Dcs1p[1][2][3][4][5][6][7]




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References

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  1. Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 SGD PMID 15161972
  2. Geerlings TH, et al. (2000) The final step in the formation of 25S rRNA in Saccharomyces cerevisiae is performed by 5'-->3' exonucleases. RNA 6(12):1698-703 SGD PMID 11142370
  3. Kim J and Kim J (2002) KEM1 is involved in filamentous growth of Saccharomyces cerevisiae. FEMS Microbiol Lett 216(1):33-8 SGD PMID 12423748
  4. Larimer FW and Stevens A (1990) Disruption of the gene XRN1, coding for a 5'----3' exoribonuclease, restricts yeast cell growth. Gene 95(1):85-90 SGD PMID 1979303
  5. Sheth U and Parker R (2003) Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300(5620):805-8 SGD PMID 12730603
  6. Sinturel F, et al. (2012) Activation of 5'-3' exoribonuclease Xrn1 by cofactor Dcs1 is essential for mitochondrial function in yeast. Proc Natl Acad Sci U S A () SGD PMID 22570495
  7. Solinger JA, et al. (1999) Active-site mutations in the Xrn1p exoribonuclease of Saccharomyces cerevisiae reveal a specific role in meiosis. Mol Cell Biol 19(9):5930-42 SGD PMID 10454540

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