Difference between revisions of "YGL092W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000003060 YGL092W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''NUP145 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''NUP145 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr VII: | + | |nowrap| Chr VII:337906..341859 |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003060 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000003060 | ||
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| − | '''Description of YGL092W:''' Essential | + | '''Description of YGL092W:''' Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural component of the Nup84p subcomplex (with roles in NPC biogenesis and localization of genes to the nuclear periphery), and an N-terminal fragment that is one of several FG-nucleoporins within the NPC central core directly responsible for nucleocytoplasmic transport; homologous to human NUP98<ref name='S000135178'>Fernandez-Martinez J and Rout MP (2009) Nuclear pore complex biogenesis. Curr Opin Cell Biol 21(4):603-12 {{SGDpaper|S000135178}} PMID 19524430</ref><ref name='S000148381'>Fernandez-Martinez J, et al. (2012) Structure-function mapping of a heptameric module in the nuclear pore complex. J Cell Biol () {{SGDpaper|S000148381}} PMID 22331846</ref><ref name='S000142476'>Fiserova J, et al. (2010) Facilitated transport and diffusion take distinct spatial routes through the nuclear pore complex. J Cell Sci 123(Pt 16):2773-80 {{SGDpaper|S000142476}} PMID 20647373</ref><ref name='S000081345'>Menon BB, et al. (2005) Reverse recruitment: the Nup84 nuclear pore subcomplex mediates Rap1/Gcr1/Gcr2 transcriptional activation. Proc Natl Acad Sci U S A 102(16):5749-54 {{SGDpaper|S000081345}} PMID 15817685</ref><ref name='S000058203'>Teixeira MT, et al. (1997) Two functionally distinct domains generated by in vivo cleavage of Nup145p: a novel biogenesis pathway for nucleoporins. EMBO J 16(16):5086-97 {{SGDpaper|S000058203}} PMID 9305650</ref><ref name='S000049611'>Teixeira MT, et al. (1999) Self-catalyzed cleavage of the yeast nucleoporin Nup145p precursor. J Biol Chem 274(45):32439-44 {{SGDpaper|S000049611}} PMID 10542288</ref><ref name='S000114163'>Therizols P, et al. (2006) Telomere tethering at the nuclear periphery is essential for efficient DNA double strand break repair in subtelomeric region. J Cell Biol 172(2):189-99 {{SGDpaper|S000114163}} PMID 16418532</ref><ref name='S000146226'>Tous C, et al. (2011) A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors. EMBO J 30(10):1953-64 |
| − | {{SGDpaper| | + | {{SGDpaper|S000146226}} PMID 21478823</ref> |
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Latest revision as of 14:05, 11 June 2012
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| Systematic name | YGL092W |
| Gene name | NUP145 |
| Aliases | RAT10 |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:337906..341859 |
| Primary SGDID | S000003060 |
Description of YGL092W: Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural component of the Nup84p subcomplex (with roles in NPC biogenesis and localization of genes to the nuclear periphery), and an N-terminal fragment that is one of several FG-nucleoporins within the NPC central core directly responsible for nucleocytoplasmic transport; homologous to human NUP98[1][2][3][4][5][6][7][8]
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References
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- ↑ Fernandez-Martinez J and Rout MP (2009) Nuclear pore complex biogenesis. Curr Opin Cell Biol 21(4):603-12 SGD PMID 19524430
- ↑ Fernandez-Martinez J, et al. (2012) Structure-function mapping of a heptameric module in the nuclear pore complex. J Cell Biol () SGD PMID 22331846
- ↑ Fiserova J, et al. (2010) Facilitated transport and diffusion take distinct spatial routes through the nuclear pore complex. J Cell Sci 123(Pt 16):2773-80 SGD PMID 20647373
- ↑ Menon BB, et al. (2005) Reverse recruitment: the Nup84 nuclear pore subcomplex mediates Rap1/Gcr1/Gcr2 transcriptional activation. Proc Natl Acad Sci U S A 102(16):5749-54 SGD PMID 15817685
- ↑ Teixeira MT, et al. (1997) Two functionally distinct domains generated by in vivo cleavage of Nup145p: a novel biogenesis pathway for nucleoporins. EMBO J 16(16):5086-97 SGD PMID 9305650
- ↑ Teixeira MT, et al. (1999) Self-catalyzed cleavage of the yeast nucleoporin Nup145p precursor. J Biol Chem 274(45):32439-44 SGD PMID 10542288
- ↑ Therizols P, et al. (2006) Telomere tethering at the nuclear periphery is essential for efficient DNA double strand break repair in subtelomeric region. J Cell Biol 172(2):189-99 SGD PMID 16418532
- ↑ Tous C, et al. (2011) A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors. EMBO J 30(10):1953-64 SGD PMID 21478823
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