Difference between revisions of "YGL040C"

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==Community Commentary==
 
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==References==
 
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Revision as of 08:17, 30 January 2007

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Systematic name YGL040C
Gene name HEM2
Aliases SLU1
Feature type ORF, Verified
Coordinates Chr VII:420561..419533


Description of YGL040C: Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus[1][2][3][4]




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Community Commentary

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References

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  1. Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 SGD PMID 14562095
  2. Borralho LM, et al. (1990) Purification of delta-aminolevulinate dehydratase from genetically engineered yeast. Yeast 6(4):319-30 SGD PMID 2204246
  3. Gollub EG, et al. (1977) Yeast mutants deficient in heme biosynthesis and a heme mutant additionally blocked in cyclization of 2,3-oxidosqualene. J Biol Chem 252(9):2846-54 SGD PMID 323256
  4. Myers AM, et al. (1987) Characterization of the yeast HEM2 gene and transcriptional regulation of COX5 and COR1 by heme. J Biol Chem 262(35):16822-9 SGD PMID 2445751

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