Difference between revisions of "YGL021W"
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| − | '''Description of YGL021W:''' Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar | + | '''Description of YGL021W:''' Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins<ref name='S000113653'>Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 {{SGDpaper|S000113653}} PMID 16169922</ref><ref name='S000060073'>Chen WN, et al. (1991) The YGL021 gene encodes a putative membrane protein with a putative leucine zipper motif. Yeast 7(3):301-3 {{SGDpaper|S000060073}} PMID 1882554</ref><ref name='S000073149'>Higgins JM (2003) Structure, function and evolution of haspin and haspin-related proteins, a distinctive group of eukaryotic protein kinases. Cell Mol Life Sci 60(3):446-62 {{SGDpaper|S000073149}} PMID 12737306</ref><ref name='S000117268'>Nespoli A, et al. (2006) Alk1 and Alk2 are two new cell cycle-regulated haspin-like proteins in budding yeast. Cell Cycle 5(13):1464-71 |
{{SGDpaper|S000117268}} PMID 16855400</ref> | {{SGDpaper|S000117268}} PMID 16855400</ref> | ||
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Latest revision as of 14:05, 31 August 2012
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| Systematic name | YGL021W |
| Gene name | ALK1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:454785..457067 |
| Primary SGDID | S000002989 |
Description of YGL021W: Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins[1][2][3][4]
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References
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- ↑ Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 SGD PMID 16169922
- ↑ Chen WN, et al. (1991) The YGL021 gene encodes a putative membrane protein with a putative leucine zipper motif. Yeast 7(3):301-3 SGD PMID 1882554
- ↑ Higgins JM (2003) Structure, function and evolution of haspin and haspin-related proteins, a distinctive group of eukaryotic protein kinases. Cell Mol Life Sci 60(3):446-62 SGD PMID 12737306
- ↑ Nespoli A, et al. (2006) Alk1 and Alk2 are two new cell cycle-regulated haspin-like proteins in budding yeast. Cell Cycle 5(13):1464-71 SGD PMID 16855400
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