YGL003C

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Systematic name YGL003C
Gene name CDH1
Aliases HCT1
Feature type ORF, Verified
Coordinates Chr VII:494178..492478
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Description of YGL003C: Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of mitotic cyclins resulting in exit from mitosis; targets the APC/C to specific substrates including CDC20, ASE1 and CIN8[1][2]



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References

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  1. Harper JW, et al. (2002) The anaphase-promoting complex: it's not just for mitosis any more. Genes Dev 16(17):2179-206 SGD PMID 12208841
  2. Visintin R, et al. (1997) CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science 278(5337):460-3 SGD PMID 9334304

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