Difference between revisions of "YGL003C"
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| − | '''Description of {{PAGENAME}}:''' Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of | + | '''Description of {{PAGENAME}}:''' Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including CDC20, ASE1, CIN8 and FIN1<ref name='S000120283'>Woodbury EL and Morgan DO (2007) Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase. Nat Cell Biol 9(1):106-12 {{SGDpaper|S000120283}} PMID 17173039</ref><ref name='S000071457'>Harper JW, et al. (2002) The anaphase-promoting complex: it's not just for mitosis any more. Genes Dev 16(17):2179-206 {{SGDpaper|S000071457}} PMID 12208841</ref><ref name='S000052656'>Visintin R, et al. (1997) CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science 278(5337):460-3 |
{{SGDpaper|S000052656}} PMID 9334304</ref> | {{SGDpaper|S000052656}} PMID 9334304</ref> | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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Revision as of 13:02, 21 February 2007
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| Systematic name | YGL003C |
| Gene name | CDH1 |
| Aliases | HCT1 |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:494178..492478 |
Description of YGL003C: Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including CDC20, ASE1, CIN8 and FIN1[1][2][3]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [4] [5]
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References
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- ↑ Woodbury EL and Morgan DO (2007) Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase. Nat Cell Biol 9(1):106-12 SGD PMID 17173039
- ↑ Harper JW, et al. (2002) The anaphase-promoting complex: it's not just for mitosis any more. Genes Dev 16(17):2179-206 SGD PMID 12208841
- ↑ Visintin R, et al. (1997) CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science 278(5337):460-3 SGD PMID 9334304
- ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ submitted by Jeff Ubersax on 2004-01-27
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