Difference between revisions of "YFR044C"

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'''Description of {{PAGENAME}}:''' Protein of unknown function; may interact with ribosomes, based on co-purification experiments; gene expression is regulated by Abf1p; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies<ref name='S000119886'>Ganguli D, et al. (2006) The alternative pathway of glutathione degradation is mediated by a novel protein complex involving three new genes in Saccharomyces cerevisiae Genetics () {{SGDpaper|S000119886}} PMID </ref><ref name='S000117178'>Reinders J, et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 {{SGDpaper|S000117178}} PMID 16823961</ref><ref name='S000115662'>Fleischer TC, et al. (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294-307 {{SGDpaper|S000115662}} PMID 16702403</ref><ref name='S000076894'>Miyake T, et al. (2004) Genome-wide analysis of ARS (autonomously replicating sequence) binding factor 1 (Abf1p)-mediated transcriptional regulation in Saccharomyces cerevisiae. J Biol Chem 279(33):34865-72 {{SGDpaper|S000076894}} PMID 15192094</ref><ref name='S000074185'>Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 {{SGDpaper|S000074185}} PMID 14562095</ref><ref name='S000069459'>Kumar A, et al. (2002) Subcellular localization of the yeast proteome. Genes Dev 16(6):707-19
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'''Description of {{PAGENAME}}:''' Probable di- and tri-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)<ref name='S000120080'>Ganguli D, et al. (2006) The alternative pathway of glutathione degradation is mediated by a novel protein complex involving three new genes in Saccharomyces cerevisiae. Genetics ()
  {{SGDpaper|S000069459}} PMID 11914276</ref>
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  {{SGDpaper|S000120080}} PMID 17179087</ref>
 
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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Revision as of 13:02, 21 February 2007

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Systematic name YFR044C
Gene name DUG1
Aliases
Feature type ORF, Verified
Coordinates Chr VI:241424..239979


Description of YFR044C: Probable di- and tri-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)[1]




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Community Commentary

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Protein Details

Protein Localization

Protein identified in a purified mitochondrial extract. [2] [3]




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References

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  1. Ganguli D, et al. (2006) The alternative pathway of glutathione degradation is mediated by a novel protein complex involving three new genes in Saccharomyces cerevisiae. Genetics () SGD PMID 17179087
  2. Ohlmeier S, et al. (2004) The yeast mitochondrial proteome, a study of fermentative and respiratory growth. J Biol Chem 279(6):3956-79 SGD PMID 14597615
  3. submitted by Steffen Ohlmeier on 2004-04-08

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