Difference between revisions of "YFR027W"

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'''Description of YFR027W:''' Acetyltransferase required for the establishment of sister chromatid cohesion during DNA replication, but not for its maintenance during G2 and M phases; also required for postreplicative double-strand break repair; interacts with Chl1p<ref name='S000076406'>Skibbens RV (2004) Chl1p, a DNA helicase-like protein in budding yeast, functions in sister-chromatid cohesion. Genetics 166(1):33-42 {{SGDpaper|S000076406}} PMID 15020404</ref><ref name='S000069235'>Ivanov D, et al. (2002) Eco1 is a novel acetyltransferase that can acetylate proteins involved in cohesion. Curr Biol 12(4):323-8 {{SGDpaper|S000069235}} PMID 11864574</ref><ref name='S000060869'>Sjogren C and Nasmyth K (2001) Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae. Curr Biol 11(12):991-5 {{SGDpaper|S000060869}} PMID 11448778</ref><ref name='S000049776'>Toth A, et al. (1999) Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication. Genes Dev 13(3):320-33 {{SGDpaper|S000049776}} PMID 9990856</ref><ref name='S000049775'>Skibbens RV, et al. (1999) Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery. Genes Dev 13(3):307-19
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'''Description of YFR027W:''' Acetyltransferase required for the establishment of sister chromatid cohesion during DNA replication and in response to double-strand breaks; also required for postreplicative double-strand break repair<ref name='S000123318'>Unal E, et al. (2007) DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7). Science 317(5835):245-8 {{SGDpaper|S000123318}} PMID 17626885</ref><ref name='S000069235'>Ivanov D, et al. (2002) Eco1 is a novel acetyltransferase that can acetylate proteins involved in cohesion. Curr Biol 12(4):323-8 {{SGDpaper|S000069235}} PMID 11864574</ref><ref name='S000060869'>Sjogren C and Nasmyth K (2001) Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae. Curr Biol 11(12):991-5 {{SGDpaper|S000060869}} PMID 11448778</ref><ref name='S000049776'>Toth A, et al. (1999) Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication. Genes Dev 13(3):320-33 {{SGDpaper|S000049776}} PMID 9990856</ref><ref name='S000049775'>Skibbens RV, et al. (1999) Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery. Genes Dev 13(3):307-19
 
  {{SGDpaper|S000049775}} PMID 9990855</ref>
 
  {{SGDpaper|S000049775}} PMID 9990855</ref>
 
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Revision as of 14:05, 4 January 2008

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Systematic name YFR027W
Gene name ECO1
Aliases CTF7
Feature type ORF, Verified
Coordinates Chr VI:207440..208285
Primary SGDID S000001923


Description of YFR027W: Acetyltransferase required for the establishment of sister chromatid cohesion during DNA replication and in response to double-strand breaks; also required for postreplicative double-strand break repair[1][2][3][4][5]




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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [6] [7]





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References

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  1. Unal E, et al. (2007) DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7). Science 317(5835):245-8 SGD PMID 17626885
  2. Ivanov D, et al. (2002) Eco1 is a novel acetyltransferase that can acetylate proteins involved in cohesion. Curr Biol 12(4):323-8 SGD PMID 11864574
  3. Sjogren C and Nasmyth K (2001) Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae. Curr Biol 11(12):991-5 SGD PMID 11448778
  4. Toth A, et al. (1999) Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication. Genes Dev 13(3):320-33 SGD PMID 9990856
  5. Skibbens RV, et al. (1999) Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery. Genes Dev 13(3):307-19 SGD PMID 9990855
  6. Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  7. submitted by Jeff Ubersax on 2004-01-27

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