Difference between revisions of "YFR027W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000001923 YFR027W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''ECO1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''ECO1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr VI: | + | |nowrap| Chr VI:207452..208297 |
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| + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000001923 | ||
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| − | '''Description of | + | '''Description of YFR027W:''' Acetyltransferase required for establishment of sister chromatid cohesion; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome<ref name='S000130406'>Heidinger-Pauli JM, et al. (2009) Distinct targets of the Eco1 acetyltransferase modulate cohesion in S phase and in response to DNA damage. Mol Cell 34(3):311-21 {{SGDpaper|S000130406}} PMID 19450529</ref><ref name='S000118836'>Lengronne A, et al. (2006) Establishment of sister chromatid cohesion at the S. cerevisiae replication fork. Mol Cell 23(6):787-99 {{SGDpaper|S000118836}} PMID 16962805</ref><ref name='S000134907'>Onn I, et al. (2009) The zinc finger of Eco1 enhances its acetyltransferase activity during sister chromatid cohesion. Nucleic Acids Res 37(18):6126-34 {{SGDpaper|S000134907}} PMID 19692582</ref><ref name='S000127161'>Rolef Ben-Shahar T, et al. (2008) Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion. Science 321(5888):563-6 {{SGDpaper|S000127161}} PMID 18653893</ref><ref name='S000060869'>Sjogren C and Nasmyth K (2001) Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae. Curr Biol 11(12):991-5 {{SGDpaper|S000060869}} PMID 11448778</ref><ref name='S000049775'>Skibbens RV, et al. (1999) Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery. Genes Dev 13(3):307-19 {{SGDpaper|S000049775}} PMID 9990855</ref><ref name='S000049776'>Toth A, et al. (1999) Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication. Genes Dev 13(3):320-33 {{SGDpaper|S000049776}} PMID 9990856</ref><ref name='S000123318'>Unal E, et al. (2007) DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7). Science 317(5835):245-8 {{SGDpaper|S000123318}} PMID 17626885</ref><ref name='S000127160'>Unal E, et al. (2008) A molecular determinant for the establishment of sister chromatid cohesion. Science 321(5888):566-9 {{SGDpaper|S000127160}} PMID 18653894</ref><ref name='S000081432'>Vega H, et al. (2005) Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion. Nat Genet 37(5):468-70 {{SGDpaper|S000081432}} PMID 15821733</ref><ref name='S000126972'>Zhang J, et al. (2008) Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol Cell 31(1):143-51 |
| − | {{SGDpaper| | + | {{SGDpaper|S000126972}} PMID 18614053</ref> |
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| + | <!-- PLEASE ADD Community Commentary ABOVE THIS MESSAGE. See below for an example of community annotation --> | ||
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| + | Specifically higher expression in carbon limited chemostat cultures versus carbon excess. | ||
| + | <ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. | ||
| + | J Biol Chem 278(5):3265-74</ref> | ||
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<protect> | <protect> | ||
Latest revision as of 07:45, 23 January 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YFR027W |
| Gene name | ECO1 |
| Aliases | CTF7 |
| Feature type | ORF, Verified |
| Coordinates | Chr VI:207452..208297 |
| Primary SGDID | S000001923 |
Description of YFR027W: Acetyltransferase required for establishment of sister chromatid cohesion; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome[1][2][3][4][5][6][7][8][9][10][11]
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Community Commentary
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [12] [13]
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References
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- ↑ Heidinger-Pauli JM, et al. (2009) Distinct targets of the Eco1 acetyltransferase modulate cohesion in S phase and in response to DNA damage. Mol Cell 34(3):311-21 SGD PMID 19450529
- ↑ Lengronne A, et al. (2006) Establishment of sister chromatid cohesion at the S. cerevisiae replication fork. Mol Cell 23(6):787-99 SGD PMID 16962805
- ↑ Onn I, et al. (2009) The zinc finger of Eco1 enhances its acetyltransferase activity during sister chromatid cohesion. Nucleic Acids Res 37(18):6126-34 SGD PMID 19692582
- ↑ Rolef Ben-Shahar T, et al. (2008) Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion. Science 321(5888):563-6 SGD PMID 18653893
- ↑ Sjogren C and Nasmyth K (2001) Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae. Curr Biol 11(12):991-5 SGD PMID 11448778
- ↑ Skibbens RV, et al. (1999) Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery. Genes Dev 13(3):307-19 SGD PMID 9990855
- ↑ Toth A, et al. (1999) Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication. Genes Dev 13(3):320-33 SGD PMID 9990856
- ↑ Unal E, et al. (2007) DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7). Science 317(5835):245-8 SGD PMID 17626885
- ↑ Unal E, et al. (2008) A molecular determinant for the establishment of sister chromatid cohesion. Science 321(5888):566-9 SGD PMID 18653894
- ↑ Vega H, et al. (2005) Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion. Nat Genet 37(5):468-70 SGD PMID 15821733
- ↑ Zhang J, et al. (2008) Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast. Mol Cell 31(1):143-51 SGD PMID 18614053
- ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ submitted by Jeff Ubersax on 2004-01-27
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