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Systematic name YFR004W
Gene name RPN11
Aliases MPR1
Feature type ORF, Verified
Coordinates Chr VI:153393..154313
Primary SGDID S000001900

Description of YFR004W: Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes[1][2][3][4]


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  1. Berndt C, et al. (2002) Ubiquitin system: JAMMing in the name of the lid. Curr Biol 12(23):R815-7 SGD PMID 12477409
  2. Guterman A and Glickman MH (2004) Complementary roles for Rpn11 and Ubp6 in deubiquitination and proteolysis by the proteasome. J Biol Chem 279(3):1729-38 SGD PMID 14581483
  3. Hofmann L, et al. (2009) A nonproteolytic proteasome activity controls organelle fission in yeast. J Cell Sci 122(Pt 20):3673-83 SGD PMID 19773362
  4. Verma R, et al. (2002) Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome. Science 298(5593):611-5 SGD PMID 12183636

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