YFL001W

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Systematic name YFL001W
Gene name DEG1
Aliases PUS3
Feature type ORF, Verified
Coordinates Chr VI:147126..148454


Description of YFL001W: Non-essential tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm[1][2][3]




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References

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  1. Lecointe F, et al. (2002) Lack of pseudouridine 38/39 in the anticodon arm of yeast cytoplasmic tRNA decreases in vivo recoding efficiency. J Biol Chem 277(34):30445-53 SGD PMID 12058040
  2. Lecointe F, et al. (1998) Characterization of yeast protein Deg1 as pseudouridine synthase (Pus3) catalyzing the formation of psi 38 and psi 39 in tRNA anticodon loop. J Biol Chem 273(3):1316-23 SGD PMID 9430663
  3. Carbone ML, et al. (1991) A gene tightly linked to CEN6 is important for growth of Saccharomyces cerevisiae. Curr Genet 19(1):1-8 SGD PMID 2036682

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