Difference between revisions of "YER169W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000971 YER169W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000971 YER169W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''RPH1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''RPH1 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr V:523364..525754
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|nowrap| Chr V:523369..525759
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000000971
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000000971
 
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'''Description of YER169W:''' JmjC domain-containing histone demethylase which can specifically demethylate H3K36 tri- and dimethyl modification states; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway<ref name='S000121953'>Klose RJ, et al. (2007) Demethylation of Histone H3K36 and H3K9 by Rph1: a Vestige of an H3K9 Methylation System in Saccharomyces cerevisiae? Mol Cell Biol 27(11):3951-61 {{SGDpaper|S000121953}} PMID 17371840</ref><ref name='S000121921'>Tu S, et al. (2007) Identification of Histone Demethylases in Saccharomyces cerevisiae. J Biol Chem 282(19):14262-71 {{SGDpaper|S000121921}} PMID 17369256</ref><ref name='S000069126'>Kim EM, et al. (2002) Phosphorylation of Rph1, a damage-responsive repressor of PHR1 in Saccharomyces cerevisiae, is dependent upon Rad53 kinase. Nucleic Acids Res 30(3):643-8 {{SGDpaper|S000069126}} PMID 11809875</ref><ref name='S000046845'>Jang YK, et al. (1999) RPH1 and GIS1 are damage-responsive repressors of PHR1. Mol Cell Biol 19(11):7630-8
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'''Description of YER169W:''' JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway<ref name='S000046845'>Jang YK, et al. (1999) RPH1 and GIS1 are damage-responsive repressors of PHR1. Mol Cell Biol 19(11):7630-8 {{SGDpaper|S000046845}} PMID 10523651</ref><ref name='S000069126'>Kim EM, et al. (2002) Phosphorylation of Rph1, a damage-responsive repressor of PHR1 in Saccharomyces cerevisiae, is dependent upon Rad53 kinase. Nucleic Acids Res 30(3):643-8 {{SGDpaper|S000069126}} PMID 11809875</ref><ref name='S000121953'>Klose RJ, et al. (2007) Demethylation of histone H3K36 and H3K9 by Rph1: a vestige of an H3K9 methylation system in Saccharomyces cerevisiae? Mol Cell Biol 27(11):3951-61 {{SGDpaper|S000121953}} PMID 17371840</ref><ref name='S000145815'>Kwon DW and Ahn SH (2011) Role of yeast JmjC-domain containing histone demethylases in actively transcribed regions. Biochem Biophys Res Commun () {{SGDpaper|S000145815}} PMID 21684259</ref><ref name='S000121921'>Tu S, et al. (2007) Identification of histone demethylases in Saccharomyces cerevisiae. J Biol Chem 282(19):14262-71
  {{SGDpaper|S000046845}} PMID 10523651</ref>
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  {{SGDpaper|S000121921}} PMID 17369256</ref>
 
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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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J Biol Chem 278(5):3265-74</ref>
 
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Latest revision as of 07:45, 23 January 2012

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Systematic name YER169W
Gene name RPH1
Aliases
Feature type ORF, Verified
Coordinates Chr V:523369..525759
Primary SGDID S000000971


Description of YER169W: JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway[1][2][3][4][5]




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References

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  1. Jang YK, et al. (1999) RPH1 and GIS1 are damage-responsive repressors of PHR1. Mol Cell Biol 19(11):7630-8 SGD PMID 10523651
  2. Kim EM, et al. (2002) Phosphorylation of Rph1, a damage-responsive repressor of PHR1 in Saccharomyces cerevisiae, is dependent upon Rad53 kinase. Nucleic Acids Res 30(3):643-8 SGD PMID 11809875
  3. Klose RJ, et al. (2007) Demethylation of histone H3K36 and H3K9 by Rph1: a vestige of an H3K9 methylation system in Saccharomyces cerevisiae? Mol Cell Biol 27(11):3951-61 SGD PMID 17371840
  4. Kwon DW and Ahn SH (2011) Role of yeast JmjC-domain containing histone demethylases in actively transcribed regions. Biochem Biophys Res Commun () SGD PMID 21684259
  5. Tu S, et al. (2007) Identification of histone demethylases in Saccharomyces cerevisiae. J Biol Chem 282(19):14262-71 SGD PMID 17369256

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