YER154W

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Systematic name YER154W
Gene name OXA1
Aliases PET1402
Feature type ORF, Verified
Coordinates Chr V:475015..476223


Description of YER154W: Translocase of the mitochondrial inner membrane, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; null is respiratory deficient[1][2][3]




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References

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  1. Szyrach G, et al. (2003) Ribosome binding to the Oxa1 complex facilitates co-translational protein insertion in mitochondria. EMBO J 22(24):6448-57 SGD PMID 14657018
  2. Jia L, et al. (2003) Yeast Oxa1 interacts with mitochondrial ribosomes: the importance of the C-terminal region of Oxa1. EMBO J 22(24):6438-47 SGD PMID 14657017
  3. Bonnefoy N, et al. (1994) Cloning of a human gene involved in cytochrome oxidase assembly by functional complementation of an oxa1- mutation in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 91(25):11978-82 SGD PMID 7991568

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