Difference between revisions of "YER129W"
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| − | '''Description of YER129W:''' Upstream kinase for the SNF1 complex; partially redundant | + | '''Description of YER129W:''' Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome<ref name='S000086812'>Elbing K, et al. (2006) Purification and characterization of the three Snf1-activating kinases of Saccharomyces cerevisiae. Biochem J 393(Pt 3):797-805 {{SGDpaper|S000086812}} PMID 16201971</ref><ref name='S000073902'>Hong SP, et al. (2003) Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases. Proc Natl Acad Sci U S A 100(15):8839-43 {{SGDpaper|S000073902}} PMID 12847291</ref><ref name='S000073782'>Sutherland CM, et al. (2003) Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex. Curr Biol 13(15):1299-305 {{SGDpaper|S000073782}} PMID 12906789</ref><ref name='S000073540'>Nath N, et al. (2003) Yeast Pak1 kinase associates with and activates Snf1. Mol Cell Biol 23(11):3909-17 {{SGDpaper|S000073540}} PMID 12748292</ref><ref name='S000052819'>Hovland PG, et al. (1997) Overexpression of the protein kinase Pak1 suppresses yeast DNA polymerase mutations. Mol Gen Genet 256(1):45-53 |
{{SGDpaper|S000052819}} PMID 9341678</ref> | {{SGDpaper|S000052819}} PMID 9341678</ref> | ||
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Revision as of 14:05, 14 August 2007
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| Systematic name | YER129W |
| Gene name | SAK1 |
| Aliases | PAK1 |
| Feature type | ORF, Verified |
| Coordinates | Chr V:417277..420705 |
| Primary SGDID | S000000931 |
Description of YER129W: Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome[1][2][3][4][5]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [6] [7]
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References
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- ↑ Elbing K, et al. (2006) Purification and characterization of the three Snf1-activating kinases of Saccharomyces cerevisiae. Biochem J 393(Pt 3):797-805 SGD PMID 16201971
- ↑ Hong SP, et al. (2003) Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases. Proc Natl Acad Sci U S A 100(15):8839-43 SGD PMID 12847291
- ↑ Sutherland CM, et al. (2003) Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex. Curr Biol 13(15):1299-305 SGD PMID 12906789
- ↑ Nath N, et al. (2003) Yeast Pak1 kinase associates with and activates Snf1. Mol Cell Biol 23(11):3909-17 SGD PMID 12748292
- ↑ Hovland PG, et al. (1997) Overexpression of the protein kinase Pak1 suppresses yeast DNA polymerase mutations. Mol Gen Genet 256(1):45-53 SGD PMID 9341678
- ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ submitted by Jeff Ubersax on 2004-01-27
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