Difference between revisions of "YER126C"

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Specifically higher expression in carbon limited chemostat cultures versus carbon excess.
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<ref>Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur.
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J Biol Chem 278(5):3265-74</ref>
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Revision as of 13:02, 21 February 2007

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Systematic name YER126C
Gene name NSA2
Aliases
Feature type ORF, Verified
Coordinates Chr V:414175..413390


Description of YER126C: Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis[1][2]




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Community Commentary

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Interactions

Genetic

YER126C is a suppressor of NOG1

Mutation type(s): overexpression, Thermosensitive

[3] [4]

Two Hybrid

Two Hybrid interaction with NOG1
[3] [4]


Protein Details

Protein Degradation

Nsa2 is unstable when large ribosomal subunit biogenesis is blocked upstream of this factor. [3] [4]


Protein Function/Process

required for the processing of ITS2 in 27SB pre-rRNAs. [3] [4]




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References

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  1. Horsey EW, et al. (2004) Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation. RNA 10(5):813-27 SGD PMID 15100437
  2. Harnpicharnchai P, et al. (2001) Composition and functional characterization of yeast 66S ribosome assembly intermediates. Mol Cell 8(3):505-15 SGD PMID 11583614
  3. 3.0 3.1 3.2 3.3 Lebreton A, et al. (2006) Nsa2 is an unstable, conserved factor required for the maturation of 27 SB pre-rRNAs. J Biol Chem 281(37):27099-108 SGD PMID 16861225
  4. 4.0 4.1 4.2 4.3 submitted by Alice Lebreton on 2006-08-01

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