Difference between revisions of "YER099C"
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| − | '''Description of YER099C:''' 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes<ref name='S000055167'>Carter AT, et al. (1997) PRS1 is a key member of the gene family encoding phosphoribosylpyrophosphate synthetase in Saccharomyces cerevisiae. Mol Gen Genet 254(2):148-56 {{SGDpaper|S000055167}} PMID 9108276</ref><ref name='S000054035'>Hernando Y, et al. (1998) PRS5, the fifth member of the phosphoribosyl pyrophosphate synthetase gene family in Saccharomyces cerevisiae, is essential for cell viability in the absence of either PRS1 or PRS3. J Bacteriol 180(23):6404-7 {{SGDpaper|S000054035}} PMID 9829955</ref><ref name='S000040328'>Hernando Y, et al. (1999) Genetic analysis and enzyme activity suggest the existence of more than one minimal functional unit capable of synthesizing phosphoribosyl pyrophosphate in Saccharomyces cerevisiae. J Biol Chem 274(18):12480-7 | + | '''Description of YER099C:''' 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication<ref name='S000055167'>Carter AT, et al. (1997) PRS1 is a key member of the gene family encoding phosphoribosylpyrophosphate synthetase in Saccharomyces cerevisiae. Mol Gen Genet 254(2):148-56 {{SGDpaper|S000055167}} PMID 9108276</ref><ref name='S000054035'>Hernando Y, et al. (1998) PRS5, the fifth member of the phosphoribosyl pyrophosphate synthetase gene family in Saccharomyces cerevisiae, is essential for cell viability in the absence of either PRS1 or PRS3. J Bacteriol 180(23):6404-7 {{SGDpaper|S000054035}} PMID 9829955</ref><ref name='S000040328'>Hernando Y, et al. (1999) Genetic analysis and enzyme activity suggest the existence of more than one minimal functional unit capable of synthesizing phosphoribosyl pyrophosphate in Saccharomyces cerevisiae. J Biol Chem 274(18):12480-7 |
{{SGDpaper|S000040328}} PMID 10212224</ref> | {{SGDpaper|S000040328}} PMID 10212224</ref> | ||
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Latest revision as of 14:05, 12 September 2012
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| Systematic name | YER099C |
| Gene name | PRS2 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr V:359061..358105 |
| Primary SGDID | S000000901 |
Description of YER099C: 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication[1][2][3]
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References
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- ↑ Carter AT, et al. (1997) PRS1 is a key member of the gene family encoding phosphoribosylpyrophosphate synthetase in Saccharomyces cerevisiae. Mol Gen Genet 254(2):148-56 SGD PMID 9108276
- ↑ Hernando Y, et al. (1998) PRS5, the fifth member of the phosphoribosyl pyrophosphate synthetase gene family in Saccharomyces cerevisiae, is essential for cell viability in the absence of either PRS1 or PRS3. J Bacteriol 180(23):6404-7 SGD PMID 9829955
- ↑ Hernando Y, et al. (1999) Genetic analysis and enzyme activity suggest the existence of more than one minimal functional unit capable of synthesizing phosphoribosyl pyrophosphate in Saccharomyces cerevisiae. J Biol Chem 274(18):12480-7 SGD PMID 10212224
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