Difference between revisions of "YER089C"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000891 YER089C] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''PTC2 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''PTC2 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr V: | + | |nowrap| Chr V:337340..335946 |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000891 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000000891 | ||
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| − | '''Description of YER089C:''' Type 2C protein phosphatase; dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; | + | '''Description of YER089C:''' Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication<ref name='S000113653'>Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 {{SGDpaper|S000113653}} PMID 16169922</ref><ref name='S000040841'>Cheng A, et al. (1999) Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases. Genes Dev 13(22):2946-57 {{SGDpaper|S000040841}} PMID 10580002</ref><ref name='S000073153'>Leroy C, et al. (2003) PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break. Mol Cell 11(3):827-35 {{SGDpaper|S000073153}} PMID 12667463</ref><ref name='S000046820'>Maeda T, et al. (1993) Mutations in a protein tyrosine phosphatase gene (PTP2) and a protein serine/threonine phosphatase gene (PTC1) cause a synthetic growth defect in Saccharomyces cerevisiae. Mol Cell Biol 13(9):5408-17 {{SGDpaper|S000046820}} PMID 8395005</ref><ref name='S000050455'>Marsolier MC, et al. (2000) Involvement of the PP2C-like phosphatase Ptc2p in the DNA checkpoint pathways of Saccharomyces cerevisiae. Genetics 154(4):1523-32 {{SGDpaper|S000050455}} PMID 10747050</ref><ref name='S000059233'>Warmka J, et al. (2001) Ptc1, a type 2C Ser/Thr phosphatase, inactivates the HOG pathway by dephosphorylating the mitogen-activated protein kinase Hog1. Mol Cell Biol 21(1):51-60 {{SGDpaper|S000059233}} PMID 11113180</ref><ref name='S000052073'>Welihinda AA, et al. (1998) Protein serine/threonine phosphatase Ptc2p negatively regulates the unfolded-protein response by dephosphorylating Ire1p kinase. Mol Cell Biol 18(4):1967-77 {{SGDpaper|S000052073}} PMID 9528768</ref><ref name='S000071972'>Young C, et al. (2002) Role of Ptc2 type 2C Ser/Thr phosphatase in yeast high-osmolarity glycerol pathway inactivation. Eukaryot Cell 1(6):1032-40 |
| − | {{SGDpaper| | + | {{SGDpaper|S000071972}} PMID 12477803</ref> |
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Latest revision as of 14:05, 12 September 2012
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| Systematic name | YER089C |
| Gene name | PTC2 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr V:337340..335946 |
| Primary SGDID | S000000891 |
Description of YER089C: Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication[1][2][3][4][5][6][7][8]
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References
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- ↑ Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 SGD PMID 16169922
- ↑ Cheng A, et al. (1999) Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases. Genes Dev 13(22):2946-57 SGD PMID 10580002
- ↑ Leroy C, et al. (2003) PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break. Mol Cell 11(3):827-35 SGD PMID 12667463
- ↑ Maeda T, et al. (1993) Mutations in a protein tyrosine phosphatase gene (PTP2) and a protein serine/threonine phosphatase gene (PTC1) cause a synthetic growth defect in Saccharomyces cerevisiae. Mol Cell Biol 13(9):5408-17 SGD PMID 8395005
- ↑ Marsolier MC, et al. (2000) Involvement of the PP2C-like phosphatase Ptc2p in the DNA checkpoint pathways of Saccharomyces cerevisiae. Genetics 154(4):1523-32 SGD PMID 10747050
- ↑ Warmka J, et al. (2001) Ptc1, a type 2C Ser/Thr phosphatase, inactivates the HOG pathway by dephosphorylating the mitogen-activated protein kinase Hog1. Mol Cell Biol 21(1):51-60 SGD PMID 11113180
- ↑ Welihinda AA, et al. (1998) Protein serine/threonine phosphatase Ptc2p negatively regulates the unfolded-protein response by dephosphorylating Ire1p kinase. Mol Cell Biol 18(4):1967-77 SGD PMID 9528768
- ↑ Young C, et al. (2002) Role of Ptc2 type 2C Ser/Thr phosphatase in yeast high-osmolarity glycerol pathway inactivation. Eukaryot Cell 1(6):1032-40 SGD PMID 12477803
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