YER078C

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Systematic name YER078C
Gene name ICP55
Aliases
Feature type ORF, Verified
Coordinates Chr V:318338..316803
Primary SGDID S000000880


Description of YER078C: Mitochondrial amino peptidase; removes amino acids YSP from the N-terminus of Nsf1p after cleavage by the mitochondrial processing peptidase (MPP); expression repressed by inositol and choline in an OPI1-dependent manner[1][2][3][4][5]




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Protein Details

Protein Localization

Protein identified in a purified mitochondrial extract. [6] [7]





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References

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  1. Reinders J, et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54 SGD PMID 16823961
  2. Santiago TC and Mamoun CB (2003) Genome expression analysis in yeast reveals novel transcriptional regulation by inositol and choline and new regulatory functions for Opi1p, Ino2p, and Ino4p. J Biol Chem 278(40):38723-30 SGD PMID 12871953
  3. Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91 SGD PMID 14562095
  4. Vogtle FN, et al. (2009) Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability. Cell 139(2):428-39 SGD PMID 19837041
  5. Naamati A, et al. (2009) Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55. J Biol Chem 284(44):30200-8 SGD PMID 19720832
  6. Ohlmeier S, et al. (2004) The yeast mitochondrial proteome, a study of fermentative and respiratory growth. J Biol Chem 279(6):3956-79 SGD PMID 14597615
  7. submitted by Steffen Ohlmeier on 2004-04-08

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