YER070W

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Systematic name YER070W
Gene name RNR1
Aliases CRT7, RIR1, SDS12
Feature type ORF, Verified
Coordinates Chr V:298948..301614
Primary SGDID S000000872


Description of YER070W: One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits[1][2]




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References

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  1. Yao R, et al. (2003) Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways. Proc Natl Acad Sci U S A 100(11):6628-33 SGD PMID 12732713
  2. Elledge SJ and Davis RW (1990) Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase. Genes Dev 4(5):740-51 SGD PMID 2199320

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