YEL062W
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| Systematic name | YEL062W |
| Gene name | NPR2 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr V:34407..36254 |
| Primary SGDID | S000000788 |
Description of YEL062W: Component of an evolutionarily conserved Npr2/3 complex that mediates downregulation of TORC1 activity in response to amino acid limitation; homolog of human NPRL2; target of Grr1p (E3 ligase); required for growth on urea and proline[1][2][3][4]
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References
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- ↑ Neklesa TK and Davis RW (2009) A Genome-Wide Screen for Regulators of TORC1 in Response to Amino Acid Starvation Reveals a Conserved Npr2/3 Complex. PLoS Genet 5(6):e1000515 SGD PMID 19521502
- ↑ Rousselet G, et al. (1995) A second nitrogen permease regulator in Saccharomyces cerevisiae. FEBS Lett 359(2-3):215-9 SGD PMID 7867803
- ↑ Schenk PW, et al. (2003) Anticancer drug resistance induced by disruption of the Saccharomyces cerevisiae NPR2 gene: a novel component involved in cisplatin- and doxorubicin-provoked cell kill. Mol Pharmacol 64(2):259-68 SGD PMID 12869630
- ↑ Spielewoy N, et al. (2010) Npr2, yeast homolog of the human tumor suppressor NPRL2, is a target of Grr1 required for adaptation to growth on diverse nitrogen sources. Eukaryot Cell 9(4):592-601 SGD PMID 20154027
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