YEL031W

From SGD-Wiki
Revision as of 13:02, 21 February 2007 by SGDwikiBot (talk | contribs) (Automated import of articles)
Jump to: navigation, search

Share your knowledge...Edit this entry! <protect>

Systematic name YEL031W
Gene name SPF1
Aliases COD1, PER9, PIO1
Feature type ORF, Verified
Coordinates Chr V:90258..93905


Description of YEL031W: P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1[1][2][3]




</protect>

Community Commentary

About Community Commentary. Please share your knowledge!

Alleles, Strains, and Phenotypes

Complete Deletion

Genotype: RHY1202
Phenotype(s): Loss of function (Null), Recessive, Viable

Deletion of COD1/SPF1 prevents the degradation of Hmg2p from being regulated. [2] [4]




<protect>

References

See Help:References on how to add references

  1. Cronin SR, et al. (2002) Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis. J Cell Biol 157(6):1017-28 SGD PMID 12058017
  2. 2.0 2.1 Cronin SR, et al. (2000) Regulation of HMG-CoA reductase degradation requires the P-type ATPase Cod1p/Spf1p. J Cell Biol 148(5):915-24 SGD PMID 10704442
  3. Suzuki C and Shimma YI (1999) P-type ATPase spf1 mutants show a novel resistance mechanism for the killer toxin SMKT. Mol Microbiol 32(4):813-23 SGD PMID 10361284
  4. submitted by Stephen R. Cronin on 2003-06-13

See Help:Categories on how to add the wiki page for this gene to a Category </protect>