Difference between revisions of "YEL031W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000000757 YEL031W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SPF1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''SPF1 '' | ||
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| − | '''Description of YEL031W:''' P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1 | + | '''Description of YEL031W:''' P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1<ref name='S000051798'>Cronin SR, et al. (2000) Regulation of HMG-CoA reductase degradation requires the P-type ATPase Cod1p/Spf1p. J Cell Biol 148(5):915-24 {{SGDpaper|S000051798}} PMID 10704442</ref><ref name='S000070157'>Cronin SR, et al. (2002) Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis. J Cell Biol 157(6):1017-28 {{SGDpaper|S000070157}} PMID 12058017</ref><ref name='S000150715'>Katrin K, et al. (2012) Ergosterol content specifies targeting of tail-anchored proteins to mitochondrial outer membranes. Mol Biol Cell () {{SGDpaper|S000150715}} PMID 22918956</ref><ref name='S000043545'>Suzuki C and Shimma YI (1999) P-type ATPase spf1 mutants show a novel resistance mechanism for the killer toxin SMKT. Mol Microbiol 32(4):813-23 |
| − | {{SGDpaper| | + | {{SGDpaper|S000043545}} PMID 10361284</ref> |
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Latest revision as of 14:05, 14 September 2012
Share your knowledge...Edit this entry! <protect>
| Systematic name | YEL031W |
| Gene name | SPF1 |
| Aliases | COD1, PER9, PIO1 |
| Feature type | ORF, Verified |
| Coordinates | Chr V:90258..93905 |
| Primary SGDID | S000000757 |
Description of YEL031W: P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1[1][2][3][4]
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Contents
Community Commentary
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Alleles, Strains, and Phenotypes
Complete Deletion
Genotype: RHY1202
Phenotype(s): Loss of function (Null), Recessive, Viable
Deletion of COD1/SPF1 prevents the degradation of Hmg2p from being regulated. [1] [5]
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References
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- ↑ 1.0 1.1 Cronin SR, et al. (2000) Regulation of HMG-CoA reductase degradation requires the P-type ATPase Cod1p/Spf1p. J Cell Biol 148(5):915-24 SGD PMID 10704442
- ↑ Cronin SR, et al. (2002) Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis. J Cell Biol 157(6):1017-28 SGD PMID 12058017
- ↑ Katrin K, et al. (2012) Ergosterol content specifies targeting of tail-anchored proteins to mitochondrial outer membranes. Mol Biol Cell () SGD PMID 22918956
- ↑ Suzuki C and Shimma YI (1999) P-type ATPase spf1 mutants show a novel resistance mechanism for the killer toxin SMKT. Mol Microbiol 32(4):813-23 SGD PMID 10361284
- ↑ submitted by Stephen R. Cronin on 2003-06-13
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