YDR470C

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Systematic name YDR470C
Gene name UGO1
Aliases
Feature type ORF, Verified
Coordinates Chr IV:1401214..1399706
Primary SGDID S000002878


Description of YDR470C: Outer membrane component of the mitochondrial fusion machinery; binds directly to Fzo1p and Mgm1p and thus links these two GTPases during mitochondrial fusion; facilitates dimerization of Fzo1p during fusion[1][2][3]




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References

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  1. Anton F, et al. (2011) Ugo1 and Mdm30 act sequentially during Fzo1-mediated mitochondrial outer membrane fusion. J Cell Sci 124(Pt 7):1126-35 SGD PMID 21385840
  2. Sesaki H and Jensen RE (2001) UGO1 encodes an outer membrane protein required for mitochondrial fusion. J Cell Biol 152(6):1123-34 SGD PMID 11257114
  3. Sesaki H and Jensen RE (2004) Ugo1p links the Fzo1p and Mgm1p GTPases for mitochondrial fusion. J Biol Chem 279(27):28298-303 SGD PMID 15087460

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