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Systematic name YDR456W
Gene name NHX1
Aliases NHA2, VPL27, VPS44
Feature type ORF, Verified
Coordinates Chr IV:1367478..1369379
Primary SGDID S000002864

Description of YDR456W: Endosomal Na+/H+ exchanger, required for intracellular sequestration of Na+; required for osmotolerance to acute hypertonic shock[1][2][3]


Community Commentary

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Concerning the entry for S. cerevisiae NHX1/NHA2: The term "NHA2" is no longer widely accepted in the ion transporter field. Rather "NHX1" is preferred based on extensive phylogenetic analyses and further studies Cite error: Closing </ref> missing for <ref> tag -->



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  1. Brett CL, et al. (2005) The yeast endosomal Na+K+/H+ exchanger Nhx1 regulates cellular pH to control vesicle trafficking. Mol Biol Cell 16(3):1396-405 SGD PMID 15635088
  2. Nass R, et al. (1997) Intracellular sequestration of sodium by a novel Na+/H+ exchanger in yeast is enhanced by mutations in the plasma membrane H+-ATPase. Insights into mechanisms of sodium tolerance. J Biol Chem 272(42):26145-52 SGD PMID 9334180
  3. Nass R and Rao R (1999) The yeast endosomal Na+/H+ exchanger, Nhx1, confers osmotolerance following acute hypertonic shock. Microbiology 145 ( Pt 11):3221-8 SGD PMID 10589731

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