Difference between revisions of "YDR399W"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002807 YDR399W]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002807 YDR399W]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''HPT1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''HPT1 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr IV:1270061..1270726
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|nowrap| Chr IV:1270068..1270733
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000002807
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000002807
 
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'''Description of YDR399W:''' Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome<ref name='S000063560'>Nussbaum RL and Caskey CT (1981) Purification and characterization of hypoxanthine-guanine phosphoribosyltransferase from Saccharomyces cerevisiae. Biochemistry 20(16):4584-90 {{SGDpaper|S000063560}} PMID 6170313</ref><ref name='S000063559'>Ali LZ and Sloan DL (1982) Studies of the kinetic mechanism of hypoxanthine-guanine phosphoribosyltransferase from yeast. J Biol Chem 257(3):1149-55 {{SGDpaper|S000063559}} PMID 7035445</ref><ref name='S000063558'>Ali LZ and Sloan DL (1986) Activation of hypoxanthine/guanine phosphoribosyltransferase from yeast by divalent zinc and nickel ions. J Inorg Biochem 28(4):407-15
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'''Description of YDR399W:''' Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome<ref name='S000063559'>Ali LZ and Sloan DL (1982) Studies of the kinetic mechanism of hypoxanthine-guanine phosphoribosyltransferase from yeast. J Biol Chem 257(3):1149-55 {{SGDpaper|S000063559}} PMID 7035445</ref><ref name='S000063558'>Ali LZ and Sloan DL (1986) Activation of hypoxanthine/guanine phosphoribosyltransferase from yeast by divalent zinc and nickel ions. J Inorg Biochem 28(4):407-15 {{SGDpaper|S000063558}} PMID 3546595</ref><ref name='S000063560'>Nussbaum RL and Caskey CT (1981) Purification and characterization of hypoxanthine-guanine phosphoribosyltransferase from Saccharomyces cerevisiae. Biochemistry 20(16):4584-90
  {{SGDpaper|S000063558}} PMID 3546595</ref>
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  {{SGDpaper|S000063560}} PMID 6170313</ref>
 
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Latest revision as of 14:05, 10 May 2012

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Systematic name YDR399W
Gene name HPT1
Aliases BRA6, HPRT
Feature type ORF, Verified
Coordinates Chr IV:1270068..1270733
Primary SGDID S000002807


Description of YDR399W: Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome[1][2][3]




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References

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  1. Ali LZ and Sloan DL (1982) Studies of the kinetic mechanism of hypoxanthine-guanine phosphoribosyltransferase from yeast. J Biol Chem 257(3):1149-55 SGD PMID 7035445
  2. Ali LZ and Sloan DL (1986) Activation of hypoxanthine/guanine phosphoribosyltransferase from yeast by divalent zinc and nickel ions. J Inorg Biochem 28(4):407-15 SGD PMID 3546595
  3. Nussbaum RL and Caskey CT (1981) Purification and characterization of hypoxanthine-guanine phosphoribosyltransferase from Saccharomyces cerevisiae. Biochemistry 20(16):4584-90 SGD PMID 6170313

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