Difference between revisions of "YDR399W"
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| − | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http:// | + | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000002807 YDR399W] |
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''HPT1 '' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name''' ||''HPT1 '' | ||
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates''' | ||
| − | |nowrap| Chr IV: | + | |nowrap| Chr IV:1270068..1270733 |
|- | |- | ||
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000002807 | |valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID''' || S000002807 | ||
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| − | '''Description of YDR399W:''' Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the | + | '''Description of YDR399W:''' Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome<ref name='S000063559'>Ali LZ and Sloan DL (1982) Studies of the kinetic mechanism of hypoxanthine-guanine phosphoribosyltransferase from yeast. J Biol Chem 257(3):1149-55 {{SGDpaper|S000063559}} PMID 7035445</ref><ref name='S000063558'>Ali LZ and Sloan DL (1986) Activation of hypoxanthine/guanine phosphoribosyltransferase from yeast by divalent zinc and nickel ions. J Inorg Biochem 28(4):407-15 {{SGDpaper|S000063558}} PMID 3546595</ref><ref name='S000063560'>Nussbaum RL and Caskey CT (1981) Purification and characterization of hypoxanthine-guanine phosphoribosyltransferase from Saccharomyces cerevisiae. Biochemistry 20(16):4584-90 |
{{SGDpaper|S000063560}} PMID 6170313</ref> | {{SGDpaper|S000063560}} PMID 6170313</ref> | ||
<br> | <br> | ||
Latest revision as of 14:05, 10 May 2012
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| Systematic name | YDR399W |
| Gene name | HPT1 |
| Aliases | BRA6, HPRT |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:1270068..1270733 |
| Primary SGDID | S000002807 |
Description of YDR399W: Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome[1][2][3]
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References
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- ↑ Ali LZ and Sloan DL (1982) Studies of the kinetic mechanism of hypoxanthine-guanine phosphoribosyltransferase from yeast. J Biol Chem 257(3):1149-55 SGD PMID 7035445
- ↑ Ali LZ and Sloan DL (1986) Activation of hypoxanthine/guanine phosphoribosyltransferase from yeast by divalent zinc and nickel ions. J Inorg Biochem 28(4):407-15 SGD PMID 3546595
- ↑ Nussbaum RL and Caskey CT (1981) Purification and characterization of hypoxanthine-guanine phosphoribosyltransferase from Saccharomyces cerevisiae. Biochemistry 20(16):4584-90 SGD PMID 6170313
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